DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and CYP4Z1

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_835235.1	Gene:	CYP4Z1 / 199974	HGNCID:	20583	Length:	505	Species:	Homo sapiens

Alignment Length:	544	Identity:	168/544 - (30%)
Similarity:	268/544 - (49%)	Gaps:	60/544 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSKVITSLMAESILLSKVGQVISGYSPITVFLLGSILIFLVV--YNKRRSRLVKYIEKIPGPAA 63
            |....:..|||...||             .:.|..|:|:|.|:  |.:|| .:::.:...|.|.|
Human     1 MEPSWLQELMAHPFLL-------------LILLCMSLLLFQVIRLYQRRR-WMIRALHLFPAPPA 51

  Fly    64 MPFLGNAIEMNVDHDELFNRVIGMQK------LWGTRIGINRVWQGTAPRVLLF---EPETVEPI 119
            ..|.|:.....|...|:::::  |:|      ||            ..|..:.|   :|:..:.:
Human    52 HWFYGHKEFYPVKEFEVYHKL--MEKYPCAVPLW------------VGPFTMFFSVHDPDYAKIL 102

  Fly   120 LNSQKFVNKSHDYDYLHPWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARK 184
            |..|. ...:..:..|..|:|.||:|....||...|:|:.|.|:..||..||.:.:|...::..|
Human   103 LKRQD-PKSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNK 166

  Fly   185 LAVEVGSEA-FNLFPYVTLCTLDIVCETAMGRRIYAQSNSE-SEYVKAVYGIGSIVQSRQAKIWL 247
            ....:...: ..||.:|:|.|||.:.:.|...:...|.:|. ..|:|||:.:..|...|......
Human   167 WEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLH 231

  Fly   248 QSDFIFSLTAEYKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLA 312
            .:|.:|..:::.::...:...||.|:..||::||..|             ......|..:|:|..
Human   232 HNDLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESL-------------KDKLKQDTTQKRRWD 283

  Fly   313 FLDLLIDASKEGTV-LSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIF 376
            |||:|:.|..|.|. .|..|::.||.||||.||||||:||||.|:.|..:||:|:|..:|:..:.
Human   284 FLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELL 348

  Fly   377 GDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTYAL 440
            ||.  :..|.::|..|.|...|||:.|||:..|..::|::.:.:.. .|:.:|||....|..:||
Human   349 GDG--SSITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWAL 411

  Fly   441 HRNPRVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIE 505
            |.||..:..|:.|||..|..||....||:|:||||||.||||||.|||:|.|..::..|.::|:
Human   412 HHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKL- 475

  Fly   506 AVDRREDLTLLGELILRPKDGLRV 529
            |.|.......:.:::|:.|:|:.|
Human   476 APDHSRPPQPVRQVVLKSKNGIHV 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	154/484 (32%)
CYP4Z1	NP_835235.1	p450	47..500	CDD:278495	154/484 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154666
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740