Protein Alignment Cyp4c3 and CYP4Z1

DIOPT Version :10

• Sequence 1: NP_524598.1
• Gene: Cyp4c3 / 43663
• FlyBaseID: FBgn0015032
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_835235.1
• Gene: CYP4Z1 / 199974
• HGNCID: 20583
• Length: 505
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 168/544 - (30%)
• Similarity: 268/544 - (49%)
• Gaps: 60/544 - (11%)

  Fly     1 MSSKVITSLMAESILLSKVGQVISGYSPITVFLLGSILIFLVV--YNKRRSRLVKYIEKIPGPAA 63
            |....:..|||...||             .:.|..|:|:|.|:  |.:|| .:::.:...|.|.|
Human     1 MEPSWLQELMAHPFLL-------------LILLCMSLLLFQVIRLYQRRR-WMIRALHLFPAPPA 51

  Fly    64 MPFLGNAIEMNVDHDELFNRVIGMQK------LWGTRIGINRVWQGTAPRVLLF---EPETVEPI 119
            ..|.|:.....|...|:::::  |:|      ||            ..|..:.|   :|:..:.:
Human    52 HWFYGHKEFYPVKEFEVYHKL--MEKYPCAVPLW------------VGPFTMFFSVHDPDYAKIL 102

  Fly   120 LNSQKFVNKSHDYDYLHPWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARK 184
            |..|. ...:..:..|..|:|.||:|....||...|:|:.|.|:..||..||.:.:|...::..|
Human   103 LKRQD-PKSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNK 166

  Fly   185 LAVEVGSEA-FNLFPYVTLCTLDIVCETAMGRRIYAQSNSE-SEYVKAVYGIGSIVQSRQAKIWL 247
            ....:...: ..||.:|:|.|||.:.:.|...:...|.:|. ..|:|||:.:..|...|......
Human   167 WEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLH 231

  Fly   248 QSDFIFSLTAEYKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLA 312
            .:|.:|..:::.::...:...||.|:..||::||..|             ......|..:|:|..
Human   232 HNDLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESL-------------KDKLKQDTTQKRRWD 283

  Fly   313 FLDLLIDASKEGTV-LSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIF 376
            |||:|:.|..|.|. .|..|::.||.||||.||||||:||||.|:.|..:||:|:|..:|:..:.
Human   284 FLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELL 348

  Fly   377 GDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTYAL 440
            ||.  :..|.::|..|.|...|||:.|||:..|..::|::.:.:.. .|:.:|||....|..:||
Human   349 GDG--SSITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWAL 411

  Fly   441 HRNPRVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIE 505
            |.||..:..|:.|||..|..||....||:|:||||||.||||||.|||:|.|..::..|.::|:
Human   412 HHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKL- 475

  Fly   506 AVDRREDLTLLGELILRPKDGLRV 529
            |.|.......:.:::|:.|:|:.|
Human   476 APDHSRPPQPVRQVVLKSKNGIHV 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	CYP4V-like	96..529	CDD:410753	142/439 (32%)
CYP4Z1	NP_835235.1	CYP4B-like	66..500	CDD:410771	148/465 (32%)