DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4c3 and cyp-13A4

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_496111.1	Gene:	cyp-13A4 / 188355	WormBaseID:	WBGene00011671	Length:	520	Species:	Caenorhabditis elegans

Alignment Length:	574	Identity:	135/574 - (23%)
Similarity:	245/574 - (42%)	Gaps:	127/574 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ITVFLLGSILIFLVVYNKRRSRLVKYI--------EKIPGPAAMPFLGNAIEMNVDHDELFNRVI 85
            :::.:.|::.|..:.|         ||        :.:.||...||.|..::.: |::.     .
Worm     3 LSLLIAGALFIGFLTY---------YIWIWSFWIRKGVKGPRGFPFFGVILKFH-DYEN-----P 52

  Fly    86 GMQKL--WGTRIG-INRVWQGTAPRVLLFEPETVEPILNSQKFVNKSHDYDY---LHPWLGE--- 141
            |:.||  |..:.| |..:.:|....:::..||.|..:     || |..|..|   .:|..|:
Worm    53 GLLKLGEWTKKYGSIYGITEGVEKTLVVSNPEFVHEV-----FV-KQFDNFYGRKTNPIQGDPNK 111

  Fly   142 ----GLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKL-AVEVGSEAFNLFPYVT 201
                .|:.:...:|...|.:.:|.|..|.|...:....|....|.|.| ......:|.:|..|..
Worm   112 NKRAHLVLAQGHRWKRLRTLASPTFSNKSLRKIMSTVEETVVELMRHLDEASAKGKAVDLLDYYQ 176

  Fly   202 LCTLDIVCETAMG---------------RRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDF 251
            ..||||:...|||               :.|:.:.......:..|:.|...:. ||
Worm   177 EFTLDIIGRIAMGQTESLMFRNPMLPKVKEIFKKGGKMPFLIAGVFPIAGTLM-RQ--------- 231

  Fly   252 IFSLTAEYKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDL 316
            :|....::......:||:....|..:.:|.|:.....|.:....:                |:||
Worm   232 LFMKFPKFSPAFGIMNTMEKALNKRLEQRAADKKAGIEPSGEPQD----------------FIDL 280

  Fly   317 LIDA-------SKEGTV-------------LSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCH 361
            .:||       .:|.|:             |:.::|..::..|:..|:|||:.::|::.:||..|
Worm   281 FLDARANVDFIEEESTLGFAKSEVLKVDKHLTFDEIIGQLFVFLLAGYDTTALSLSYSSYLLATH 345

  Fly   362 PEYQERVVEELDSIFGDDKETP---ATMKNLMDMRYLECCIKDSLRLFPSVPMM-ARMVGEDVNI 422
            ||.|:::.||:      |:|.|   .|...:..::|:||.:|::||::|...:: .|...:..|:
Worm   346 PEIQKKLQEEV------DRECPDPEVTFDQISKLKYMECVVKEALRMYPLASLVHNRKCMKKTNV 404

  Fly   423 GGKIVPAGTQAIIMTYALHRNPRVFP------KPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNC 481
            .|..:..||...:.|:.||.:|:|:.      |||::...:.|.....|     |:||..|||.|
Worm   405 LGVEIDEGTNVQVDTWTLHYDPKVWGDDASEFKPERWETGDELFYAKGG-----YLPFGMGPRIC 464

  Fly   482 IGQKFAILEEKAVISTVLRKYKIEAVDRRE-DLTLLGELILRPKDGLRVKITPR 534
            ||.:.|::|||.:::.:|:||..:.....| .|.|:|...:.|:: :.:|:|||
Worm   465 IGMRLAMMEEKLLLTHILKKYTFDTSTETEIPLKLVGSATIAPRN-VMLKLTPR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	126/531 (24%)
cyp-13A4	NP_496111.1	p450	33..514	CDD:278495	126/530 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900