DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4c3 and cyp-37A1

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_496939.2	Gene:	cyp-37A1 / 175053	WormBaseID:	WBGene00008499	Length:	508	Species:	Caenorhabditis elegans

Alignment Length:	532	Identity:	224/532 - (42%)
Similarity:	300/532 - (56%)	Gaps:	54/532 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ITVFLLGSILIFLVVYN--------KRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDHDE----LF 81
            |.|:||..::|: ||:|        |.|.||...:.||.||.|:|.||...:..:|..|    |:
Worm     3 IAVYLLALVVIY-VVFNLSKILKFVKERMRLYHLMSKIDGPLALPLLGTTFQFKMDPVEFALQLY 66

  Fly    82 NRVIGMQKLWGTRI-----GINRVWQGTAPRVLLFEPETVEPILNSQKFVNKSHDYDYLHPWLGE 141
            |        ||...     .:...|.|..|.|::..||..:.:|.|...:|||.:||...||||.
Worm    67 N--------WGLEYSTKGSSLAAFWMGPYPMVIVLTPEANKKVLESNALINKSSEYDIFLPWLGT 123

  Fly   142 GLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKL---AVEVGSEAFNLFPYVTLC 203
            |||.::..||..|||::||:|||.:|.||..|||.||.:|..::   |.:......:.|||:..|
Worm   124 GLLLASGEKWRGRRKMMTPSFHFNVLIDFQVVFNSQSMILLEQIENAAKKTDDSTIDAFPYIKRC 188

  Fly   204 TLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINT 268
            .|||:||||||..:.||:|....||.||..:.|:....|...||....|..|.......|..::.
Worm   189 ALDIICETAMGTTVSAQTNHTHPYVVAVNEMNSLAFKYQRMPWLWIKPIRQLIGYEADFQRNLDI 253

  Fly   269 LHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKEGTVLSNEDIR 333
            :..|:..|| :||     |:|   ::..:.....::..|||  ||||:||:..:||. |..||||
Worm   254 VTSFTKKVI-DRK-----LRE---HDETDGMVVVEEESKKK--AFLDMLIEKKEEGG-LGYEDIR 306

  Fly   334 EEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIF-GDDKETPATMKNLMDMRYLEC 397
            ||||||||||||||||.|.|:|:.|...||||::..||||.|| |..:|  .::::|..|:|||.
Worm   307 EEVDTFMFEGHDTTSAGIGWSLWCLANCPEYQKKCHEELDEIFEGTSRE--CSVEDLKKMKYLEK 369

  Fly   398 CIKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPEN 462
            |:|::||:.||||.|||.|.|:|.|.|||:|.|...:|....:..|||.||..|.|:|:.|..:.
Worm   370 CVKEALRMRPSVPQMARSVEEEVEIDGKILPKGCSVMISPAFIQNNPRTFPNHEVFDPERFNEDE 434

  Fly   463 CAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTL-----LGELILR 522
            .:.||.:||||||||||||||||||:.|||.|||.|||::.|..     |:.|     |.|.|.|
Worm   435 ISKRHAYAYIPFSAGPRNCIGQKFAMQEEKTVISWVLRRFHIHT-----DIGLLENMPLPETITR 494

  Fly   523 PKDGLRVKITPR 534
            |..|..:|.|.|
Worm   495 PSLGFPLKFTVR 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	207/489 (42%)
cyp-37A1	NP_496939.2	p450	41..503	CDD:278495	207/488 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H133054
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28797
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.790