Protein Alignment Cyp4c3 and Cyp3a9

DIOPT Version :10

• Sequence 1: NP_524598.1
• Gene: Cyp4c3 / 43663
• FlyBaseID: FBgn0015032
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_671739.2
• Gene: Cyp3a9 / 171352
• RGDID: 708392
• Length: 503
• Species: Rattus norvegicus
• Alignment Length: 543
• Identity: 143/543 - (26%)
• Similarity: 257/543 - (47%)
• Gaps: 77/543 - (14%)

  Fly    22 VISGYSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNV---DHDELFNR 83
            :|..:|..|..||...|:.|.:|......:.|.: .||||..:||||..:....   :.|:..::
  Rat     3 LIPNFSMETWLLLVISLVLLYLYGTHSHGIFKKL-GIPGPKPLPFLGTILAYRKGFWEFDKYCHK 66

  Fly    84 VIGMQKLWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQ---KFVNKSHDYDYLHP--WLGEGL 143
            ..|  ||||       ::.|..|.:.:.:|:.::.:|..:   .|.|:.:    ..|  .|.:.:
  Rat    67 KYG--KLWG-------LYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRN----FGPVGILKKAI 118

  Fly   144 LTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVGSE---------AFNLFPY 199
            ..|.|.:|...|.:|:|.|....|.:...:.|:.:.:|.|.:  ..|||         .|..:
  Rat   119 SISEDEEWKRIRALLSPTFTSGKLKEMFPIINQYTDMLVRNM--RQGSEEGKPTSMKDIFGAY-- 179

  Fly   200 VTLCTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQS 264
                ::|::..|:.|..:.:.:|.:..:|:.:            |..|:.|....|.....|. .
  Rat   180 ----SMDVITATSFGVNVDSLNNPQDPFVEKI------------KKLLKFDIFDPLFLSVTLF-P 227

  Fly   265 YINTLHGFSNM------VIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKE 323
            ::..|....|:      ||...|..:..::||.....           :|:|:.||.|:|::...
  Rat   228 FLTPLFEALNVSMFPRDVIDFFKTSVERMKENRMKEK-----------EKQRMDFLQLMINSQNS 281

  Fly   324 GT-----VLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETP 383
            ..     .||:.:|..:...|:|.|::|||:|:|:.|:||..||:.|:::.:|:|:..  ..:..
  Rat   282 KVKDSHKALSDVEIVAQSVIFIFAGYETTSSALSFVLYLLAIHPDIQKKLQDEIDAAL--PNKAH 344

  Fly   384 ATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFP 448
            ||...|:.|.||:..:.::|||:|....:.|:...||.|.|..:|.||..:|.|:|||::|..:|
  Rat   345 ATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTDVEINGVFIPKGTVVMIPTFALHKDPHYWP 409

  Fly   449 KPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRRE-D 512
            :||:|.|:.|..:|....:|:.|:||..|||||||.:||::..|..:..||:.:..:.....: .
  Rat   410 EPEEFRPERFSKKNQDNINPYMYLPFGNGPRNCIGMRFALMNMKVALVRVLQNFSFQPCKETQIP 474

  Fly   513 LTLLGELILRPKDGLRVKITPRD 535
            |.|..:.:|:|:..|.:|:..||
  Rat   475 LKLSKQGLLQPEKPLLLKVVSRD 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	CYP4V-like	96..529	CDD:410753	117/458 (26%)
Cyp3a9	NP_671739.2	CYP3A	67..492	CDD:410743	122/471 (26%)