DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4c3 and Cyp3a62

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001019403.1	Gene:	Cyp3a62 / 170509	RGDID:	1595919	Length:	497	Species:	Rattus norvegicus

Alignment Length:	541	Identity:	136/541 - (25%)
Similarity:	256/541 - (47%)	Gaps:	73/541 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VISGYSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMN---VDHDELFNR 83
            :|...|..|..||.:||:.|.:|........|.: .|.||..:||:||.:...   .:.|...::
  Rat     3 LIPNISLETWMLLATILVLLYLYGTSTHGNFKKL-GISGPKPLPFVGNILAYRHGFWEFDRHCHK 66

  Fly    84 VIGMQKLWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQ---KFVNKSHDYDYLHP--WLGEGL 143
            ..|  .:||       .::|..|.:.:.:|:.::.:|..:   .|.|:..    ..|  .|.:.:
  Rat    67 KYG--DIWG-------FYEGRQPILAITDPDIIKTVLVKECYSTFTNRRS----FGPAGILKKAI 118

  Fly   144 LTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLAR--KLAVEVGS-----EAFNLFPYVT 201
            ..|.|.:|...|.:|:|.|....|.:...:.|:.:.:|.:  |...|.|:     :.|..:
  Rat   119 TLSEDEEWKRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNVKHEAEKGNPITMKDIFGAY---- 179

  Fly   202 LCTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFS------LTAEYK 260
              ::|::..|:.|..:.:.:|.::.:|:.|        .:..|......|..|      ||..::
  Rat   180 --SMDVITGTSFGVNVDSLNNPQNPFVQKV--------KKLLKFNFLDPFFLSVILFPFLTPVFE 234

  Fly   261 LHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKEGT 325
            .....:     |...|::..:..:..::||.....           .|:||.||.|:|::...|.
  Rat   235 AFDITV-----FPKDVMKFFRTSVERMKENRMQEK-----------VKQRLDFLQLMINSQSSGD 283

  Fly   326 VLSNEDIRE-EVDT----FMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPAT 385
            ..|::.:.: |:..    |:|.|::|||:|:|:.|:||..||:.|:::.:|:|:..  ..:.|.|
  Rat   284 KESHQGLTDVEIVAQSIFFIFAGYETTSSALSFALYLLATHPDLQKKLQDEIDAAL--PNKAPVT 346

  Fly   386 MKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPKP 450
            ...|::|.||:..:.::|||||....:.|:..:||.|.|..:|.||..::.|:|||::|:.:|:|
  Rat   347 YDVLVEMEYLDMVLNETLRLFPVGGRLERVCKKDVEINGVFIPKGTVVMVPTFALHKDPKCWPEP 411

  Fly   451 EQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRRE-DLT 514
            |:|.|:.|..:|....:|:.|:||..|||||||.:||::..|..:..||:.:........: .|.
  Rat   412 EEFCPERFRKKNQDSINPYIYLPFGNGPRNCIGMRFALMNMKIALVRVLQNFSFGLCKETQIPLK 476

  Fly   515 LLGELILRPKDGLRVKITPRD 535
            |..:...:|:..:.::...||
  Rat   477 LRKKGFFQPEKPIILRAVSRD 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	123/498 (25%)
Cyp3a62	NP_001019403.1	p450	39..491	CDD:278495	123/496 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810