DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4c3 and CYP4B1

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001093242.1	Gene:	CYP4B1 / 1580	HGNCID:	2644	Length:	512	Species:	Homo sapiens

Alignment Length:	535	Identity:	181/535 - (33%)
Similarity:	278/535 - (51%)	Gaps:	50/535 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SILLSKVGQVISGYSPITVFLLGSI-LIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVD 76
            |:..|.:|...||    .:.:||.: ||.|::   ||..|.|.::|.|||......|:|:|  :.
Human     7 SLSFSSLGLWASG----LILVLGFLKLIHLLL---RRQTLAKAMDKFPGPPTHWLFGHALE--IQ 62

  Fly    77 HDELFNRVIG-------MQKLW-GTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNKSHD-Y 132
            .....::|:.       ...|| |..||.          :.::||:..:.:.:  :...|:.| |
Human    63 ETGSLDKVVSWAHQFPYAHPLWFGQFIGF----------LNIYEPDYAKAVYS--RGDPKAPDVY 115

  Fly   133 DYLHPWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEV-GSEAFNL 196
            |:...|:|.|||.....||...||:|||.||:.:|..::.||.|.:.::..|...:. ..::|::
Human   116 DFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI 180

  Fly   197 FPYVTLCTLDIVCETAMGRRIYAQSNS-ESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYK 260
            |..|....|:.:.:...||......:| :|.|..||..:..::|.|.......:|||:.||...:
Human   181 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGR 245

  Fly   261 LHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKEGT 325
            .........|..::.|||||||  |:..|.......|          ::.|.|||:|:.|..|..
Human   246 RFLRACQVAHDHTDQVIRERKA--ALQDEKVRKKIQN----------RRHLDFLDILLGARDEDD 298

  Fly   326 V-LSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNL 389
            : ||:.|:|.|||||||||||||::.|||.|:.:..:||:|.|..||:..|.||  :......:|
Human   299 IKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGD--QDFFQWDDL 361

  Fly   390 MDMRYLECCIKDSLRLFPSVPMMARMVGEDVN-IGGKIVPAGTQAIIMTYALHRNPRVFPKPEQF 453
            ..|.||..|||:|.||:|.||.:.|.:.:.|. :.|:.:|||:...:..||||||..|:|.||.|
Human   362 GKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVF 426

  Fly   454 NPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGE 518
            :...|..||.:.|||||::||||||||||||:||:.|.|.|.:..|.:::......|..:. :.:
Human   427 DSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIK-MPQ 490

  Fly   519 LILRPKDGLRVKITP 533
            |:||.|:|..:.:.|
Human   491 LVLRSKNGFHLHLKP 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	165/484 (34%)
CYP4B1	NP_001093242.1	p450	47..501	CDD:306555	165/482 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154689
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650