DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and CYP4A11

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_000769.2	Gene:	CYP4A11 / 1579	HGNCID:	2642	Length:	519	Species:	Homo sapiens

Alignment Length:	542	Identity:	178/542 - (32%)
Similarity:	290/542 - (53%)	Gaps:	57/542 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SLMAESILLSKVGQVISGYSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIE 72
            |:::.|.||..|..::...|.:.:.||   ||..|.....|..|:|.:::.|.|.:....|:..|
Human     4 SVLSPSRLLGDVSGILQAASLLILLLL---LIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQE 65

  Fly    73 MNVDHDELFNRVIGMQK------------LWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQKF 125
            :..|.:  ..|:   ||            |||.::           ||.|::|:.::.||....
Human    66 LQQDQE--LQRI---QKWVETFPSACPHWLWGGKV-----------RVQLYDPDYMKVILGRSD- 113

  Fly   126 VNKSH-DYDYLHPWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEV 189
             .||| .|.:|.||:|.|||....:.|...|::||||||:.||..::.:..:...|:..|....:
Human   114 -PKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELL 177

  Fly   190 GSEA-FNLFPYVTLCTLDIVCETAMGRR--IYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDF 251
            |.:: ..:|.:|:|.|||.:.:.|...:  |....||:| |::|:..:.::|.||....:.|:|.
Human   178 GQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQS-YIQAISDLNNLVFSRVRNAFHQNDT 241

  Fly   252 IFSLTAEYKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDL 316
            |:|||:..:.........|..::.||:.|||:   ||:...         .:.:.:|:.|.|||:
Human   242 IYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQ---LQKEGE---------LEKIKRKRHLDFLDI 294

  Fly   317 LIDASKE-GTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDK 380
            |:.|..| |::||::|:|.|||||||||||||::.|||.|:.|..||::|||..||:.|:.||.
Human   295 LLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDG- 358

  Fly   381 ETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTYALHRNP 444
             ...|..:|..|.|...|||::|||:|.||.:.|.:...|.. .|:.:|.|...::..|.||.||
Human   359 -ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNP 422

  Fly   445 RVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDR 509
            :|:|.||.|:|..|.|.  :.:|..|::|||.|.|||||::||:.|.|...:..|.::::.....
Human   423 KVWPNPEVFDPFRFAPG--SAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPT 485

  Fly   510 REDLTLLGELILRPKDGLRVKI 531
            |..:. :..|:|:.|:|:.:::
Human   486 RIPIP-IARLVLKSKNGIHLRL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	164/489 (34%)
CYP4A11	NP_000769.2	p450	52..505	CDD:278495	164/488 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154674
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650