Protein Alignment Cyp4c3 and CYP3A7

DIOPT Version :9

• Sequence 1: NP_524598.1
• Gene: Cyp4c3 / 43663
• FlyBaseID: FBgn0015032
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 136/537 - (25%)
• Similarity: 245/537 - (45%)
• Gaps: 81/537 - (15%)

  Fly    30 TVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDH----DELFNRVIGMQKL 90
            |..||...||.|.:|..|...|.|.: .||||..:||||||:.....:    .|.:.:   .:|:
Human    11 TWLLLAVSLILLYLYGTRTHGLFKKL-GIPGPTPLPFLGNALSFRKGYWTFDMECYKK---YRKV 71

  Fly    91 WGTRIGINRVWQGTAPRVLLFEPETVEPILNSQ---KFVNKSHDYDYLHPWLGEGLLTST----- 147
            ||       ::....|.:.:.:|:.::.:|..:   .|.|:       .|:...|.:.:.
Human    72 WG-------IYDCQQPMLAITDPDMIKTVLVKECYSVFTNR-------RPFGPVGFMKNAISIAE 122

  Fly   148 DRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKL--AVEVGSEAFNLFPYVTL------CT 204
            |.:|...|.:|:|.|....|.:.:.:..:...||.|.|  ..|.|..       |||      .:
Human   123 DEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKP-------VTLKHVFGAYS 180

  Fly   205 LDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQ----SDFIFSLTAEYKLHQSY 265
            :|::..|:.|..|.:.:|.:..:|:            ..|..|:    ..|:.|:..     ..:
Human   181 MDVITSTSFGVSIDSLNNPQDPFVE------------NTKKLLRFNPLDPFVLSIKV-----FPF 228

  Fly   266 INTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDA-----SKEGT 325
            :..:....|:.:..||....:.:...........:.     :|.|:.||.|:||:     |:...
Human   229 LTPILEALNITVFPRKVISFLTKSVKQIKEGRLKET-----QKHRVDFLQLMIDSQNSKDSETHK 288

  Fly   326 VLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLM 390
            .||:.::..:...|:|.|::|||:.:|:.::.|..||:.|::|.:|:|::.  ..:.|.|...::
Human   289 ALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVL--PNKAPPTYDTVL 351

  Fly   391 DMRYLECCIKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNP 455
            .:.||:..:.::|||||....:.|:..:||.|.|..:|.|...:|.:|.||.:|:.:.:||:|.|
Human   352 QLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLP 416

  Fly   456 DNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRRE-DLTL-LGE 518
            :.|..:|.....|:.|.||.:|||||||.:||::..|..:..||:.:..:.....: .|.| .|.
Human   417 ERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGG 481

  Fly   519 LILRPKDGLRVKITPRD 535
            |:|..|. :.:|...||
Human   482 LLLTEKP-IVLKAESRD 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	122/502 (24%)
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	122/501 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810