DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_031849.1	Gene:	Cyp4b1 / 13120	MGIID:	103225	Length:	511	Species:	Mus musculus

Alignment Length:	540	Identity:	180/540 - (33%)
Similarity:	285/540 - (52%)	Gaps:	52/540 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MAESIL---LSKVGQVISGYSPITVFLLGSILIFLVVYNK------RRSRLVKYIEKIPGPAAMP 65
            ||.|.|   ||::|            |..|::|.:|...|      ||.:|.:.::..|||....
Mouse     1 MALSFLSPSLSRLG------------LWASVVILMVTVLKLLSLLFRRQKLARALDSFPGPPKHW 53

  Fly    66 FLGNAIEMNVDHDELFNRVIGMQKL--WGTRIG-INRVWQGTAPRVL-LFEPETVEPILNSQKFV 126
            ..|:|:|:        .:..|:.|:  |..:.. .:.:|.|.....| ::||:..:.:. |:...
Mouse    54 LFGHALEI--------QKTGGLDKVVTWTEQFPYAHPLWLGQFIVFLNIYEPDYAKAVY-SRGDP 109

  Fly   127 NKSHDYDYLHPWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVG- 190
            ..::.||:...|:|:|||.....||...||:|||.||:.:|..::.:|.|.:.|:..|...:..
Mouse   110 KAAYVYDFFLQWIGKGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRVMLDKWEKKASE 174

  Fly   191 SEAFNLFPYVTLCTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSL 255
            :::|::|..|....||.:.:...|:.....|:|::.|..||..:..::|.|.......:|||:.|
Mouse   175 NKSFDIFCDVGHMALDTLMKCTFGKGDSGLSHSDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWL 239

  Fly   256 TAEYKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDA 320
            |...:.........|..::.|||:|||.|...:|...            :.:::.|.|||:|:.|
Mouse   240 TPHGRRFLRACQIAHDHTDHVIRQRKAALQDEKEQKK------------LQERRHLDFLDILLGA 292

  Fly   321 SKE-GTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPA 384
            ..| |..||:.|:|.|||||||||||||::.|||.|:.:..:|.:|:|..||:..|.||  ....
Mouse   293 RDESGIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPMHQQRCREEVREILGD--RDSF 355

  Fly   385 TMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVN-IGGKIVPAGTQAIIMTYALHRNPRVFP 448
            ...:|..|.||..|:|:..||:|.||.:.|.:.:.|. :.|:.:|||:...:..||||||..|:|
Mouse   356 QWDDLAQMTYLTMCMKECFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISLHIYALHRNSAVWP 420

  Fly   449 KPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDL 513
            .||.|:|..|.|||..||||||::||||||||||||:||:.|.|.|.:..|.:::. :.|..:..
Mouse   421 DPEVFDPLRFSPENMTGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEF-SPDPSKIP 484

  Fly   514 TLLGELILRPKDGLRVKITP 533
            ..:.:||||.|:|:.:.:.|
Mouse   485 IKVPQLILRSKNGIHLYLKP 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	164/478 (34%)
Cyp4b1	NP_031849.1	p450	47..500	CDD:278495	164/476 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845013
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650