DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and Cyp4a12b

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_758510.2	Gene:	Cyp4a12b / 13118	MGIID:	3611747	Length:	508	Species:	Mus musculus

Alignment Length:	541	Identity:	164/541 - (30%)
Similarity:	286/541 - (52%)	Gaps:	47/541 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSKVITSLMAESILLSKVGQVISGYSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMP 65
            ||:..::|:.... .:|:..||.|..| :.:.|..:..::|     .|..|:...::.|.|.:..
Mouse     1 MSASALSSIRFPG-SISEYLQVASVLS-LLLLLFKTAQLYL-----HRQWLLSSTQQFPSPPSHW 58

  Fly    66 FLGNAIEMNVDHDELFNRVIGM-----QKLWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQKF 125
            ..|:.|..:.|..::..|:...     |.|||:::           |:.:::|:.::.||....
Mouse    59 LFGHKILKDQDLQDILTRIKNFPSACPQWLWGSKV-----------RIQVYDPDYMKLILGRSD- 111

  Fly   126 VNKSH-DYDYLHPWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEV 189
             .|:| .|.:|.||:|.|||....:.|...|::||||||:.||..:.::..:...|:..|....|
Mouse   112 -PKAHGSYRFLAPWIGRGLLLLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVHVMLDKWEQIV 175

  Fly   190 GSEA-FNLFPYVTLCTLDIVCETAMGRRIYAQSNSE-SEYVKAVYGIGSIVQSRQAKIWLQSDFI 252
            |.:: ..:|.::||.|||.:.:.|.......|.:.: ..|::||..:.::...|...|:.|:|.|
Mouse   176 GQDSTLEIFQHITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQAVEDLNNLFFLRVRNIFHQNDII 240

  Fly   253 FSLTAEYKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLL 317
            :.:::...|..|.....|..::.||:.|:::|...:|            .:.:.||:||.|||:|
Mouse   241 YRVSSNGCLANSACQLAHDHTDQVIKSRRSQLQDEEE------------LEKLKKKRRLDFLDIL 293

  Fly   318 IDASKE-GTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKE 381
            :.|..| |..||::|:|.|||||||||||||::.|||..:.|..:||:|:|..:|:.|:.||.
Mouse   294 LFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGDG-- 356

  Fly   382 TPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTYALHRNPR 445
            ...|..:|..|.|...|||::||::|.||.::|.:...|.. .|:.:|.|...::..|.||.||.
Mouse   357 ASITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDGRSLPKGIHVMLSFYGLHHNPT 421

  Fly   446 VFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRR 510
            |:|.||.|:|..|.|.  :.||..:::|||.|.|||||::||:.|.|..::..|.::::.....|
Mouse   422 VWPNPEVFDPSRFAPG--SSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTR 484

  Fly   511 EDLTLLGELILRPKDGLRVKI 531
            ..:. :..::|:.|:|:.:.:
Mouse   485 VPIP-IPRIVLKSKNGIHLHL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	152/481 (32%)
Cyp4a12b	NP_758510.2	CYP4B-like	70..503	CDD:410771	147/462 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844962
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650