DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4c3 and Cyp46a1

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_034140.1	Gene:	Cyp46a1 / 13116	MGIID:	1341877	Length:	500	Species:	Mus musculus

Alignment Length:	536	Identity:	143/536 - (26%)
Similarity:	235/536 - (43%)	Gaps:	83/536 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VFLLGSILIF-----LVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDHDELFNRV-----I 85
            :.||||.::.     ....::.|||    .|.||||....||...:......||...||     :
Mouse     5 LLLLGSAVLLAFGLCCTFVHRARSR----YEHIPGPPRPSFLLGHLPYFWKKDEDCGRVLQDVFL 65

  Fly    86 GMQKLWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNKSHDYDYLHPWLGE-----GLLT 145
            ...|.:|..:.:| |:..|:  |::..||:|:..|.|.|:...|..|..|....||     ||::
Mouse    66 DWAKKYGPVVRVN-VFYKTS--VIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVS 127

  Fly   146 STD-RKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEV-GSEAFNLFPYVTLCTLDIV 208
            ..| .:|:.:||::..||....|...::.|||::..|...|..:. |....::...:|..|:||:
Mouse   128 ECDYGRWYKQRKVMDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTCATIDIL 192

  Fly   209 CETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHGF- 272
            .:.|.|........::....:||            |:.|:     .::|..       |||..|
Mouse   193 AKAAFGMETSMLLGAQKPLSQAV------------KVMLE-----GISASR-------NTLAKFM 233

  Fly   273 --SNMVIRERKAELAILQENNNNNNNNAPDAYDDVGK----KKRLAF-------LDLLIDASK-E 323
              ....:||.:..:.:|::               |||    ::|.|.       .|:|....| |
Mouse   234 PGKRKQLREIRESIRLLRQ---------------VGKDWVQRRREALKRGEDMPADILTQILKAE 283

  Fly   324 GTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKN 388
            .....:|.:.:...||...||:|::..:::|:..|...||...|:..|:|.:.|..:.  ...::
Mouse   284 EGAQDDEVLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRH--LDYED 346

  Fly   389 LMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPKPEQF 453
            |..::||...:|:||||:|......|::.|:..|.|..||..|..:..||.:.|....|..|..|
Mouse   347 LGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTF 411

  Fly   454 NPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGE 518
            |||.|.|.  |.:..|.|.|||.|.|:||||:||.:|.|.|::.:|::.:...|..:. ..|..:
Mouse   412 NPDRFGPG--APKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIEFRLVPGQR-FGLQEQ 473

  Fly   519 LILRPKDGLRVKITPR 534
            ..|:|.|.:...:.||
Mouse   474 ATLKPLDPVLCTLRPR 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	132/498 (27%)
Cyp46a1	NP_034140.1	p450	34..466	CDD:278495	128/477 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810