Protein Alignment Cyp4c3 and Cyp3a16

DIOPT Version :10

• Sequence 1: NP_524598.1
• Gene: Cyp4c3 / 43663
• FlyBaseID: FBgn0015032
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_031846.2
• Gene: Cyp3a16 / 13114
• MGIID: 106099
• Length: 504
• Species: Mus musculus
• Alignment Length: 539
• Identity: 143/539 - (26%)
• Similarity: 261/539 - (48%)
• Gaps: 68/539 - (12%)

  Fly    22 VISGYSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAI-------EMNVDHDE 79
            :.|..|..|:.||..||:.|..|......|.|. :.||||..:||||..:       :.:::..|
Mouse     3 LFSALSLDTLVLLAIILVLLYRYGTCTHGLFKK-QGIPGPKPLPFLGTVLNYYKGLWKFDMECYE 66

  Fly    80 LFNRVIGMQKLWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNKSHDYDYLHPW-LGEGL 143
            .:.      |.||       ::.|..|..::.:|||::.:|..:.|...::..|:.... :.:.:
Mouse    67 KYG------KTWG-------LFDGQIPLFVITDPETIKNVLVKECFSVFTNRQDFFPVGIMSKSI 118

  Fly   144 LTSTDRKWHSRRKILTPAF-------HFKILDDFIDV---FNEQSAVLARKLAVEVGSEAFNLFP 198
            ..:.|.:|...|.:|:|.|       .|.:::.:.|:   :..|.|...:.:||:....|:
Mouse   119 SLAKDEEWKRYRALLSPTFTSGNLKEMFPVIEQYGDILVKYLRQEAEKGKPVAVKDVLGAY---- 179

  Fly   199 YVTLCTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQ 263
                 ::|::..|..|..|.:.:|.|..:|:            .||..|:.|:...|:....|.
Mouse   180 -----SMDVIISTTFGVNIDSLNNPEDPFVE------------NAKKVLRFDYFDPLSLSVALF- 226

  Fly   264 SYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDA---SKE-- 323
            .::..::...|:.:.. |..:...::..:....|..|:    .:|.|:.|:.|:::|   ||:
Mouse   227 PFLTPIYEMLNICMFP-KDSIEFFKKFVDRMTENRLDS----KQKHRVDFIYLMMEAYNKSKDKD 286

  Fly   324 -GTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMK 387
             ...||..:|..:...|:|.|::|||:.:|:|::.|..||:.|:::.||:|...  ..:.|.|..
Mouse   287 SHKALSEIEITAQSIIFIFAGYETTSSILSFTVYSLATHPDIQKKLQEEIDEAL--PNKAPPTYD 349

  Fly   388 NLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPKPEQ 452
            .:|.|.||:..:.::|||:|....:.|:..:||.|.|..:|.|:..||.:|.||.:|:.:|:||:
Mouse   350 TVMAMEYLDMVLNETLRLYPITNRLQRVCKKDVEINGIYIPKGSTVIIPSYVLHHDPQHWPEPEE 414

  Fly   453 FNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRRE-DLTLL 516
            |.|:.|..||.....|:.|:||..|||||||.:||::..|..:..||:.:..:.....: .|.|.
Mouse   415 FQPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALIKVLQNFSFQPCKETQIPLKLS 479

  Fly   517 GELILRPKDGLRVKITPRD 535
            .||:|:|...:.:|:.|||
Mouse   480 RELLLQPVKPIVLKVVPRD 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	CYP4V-like	96..529	CDD:410753	116/450 (26%)
Cyp3a16	NP_031846.2	CYP3A	67..493	CDD:410743	119/467 (25%)