DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and Cyp3a11

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus

Alignment Length:	548	Identity:	140/548 - (25%)
Similarity:	261/548 - (47%)	Gaps:	86/548 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VISGYSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDHDELFNRVIG 86
            ::|..|..|..||...|:.|..|..|:..|.|. :.||||..:||||..:          |...|
Mouse     3 LVSALSLETWVLLAISLVLLYRYGTRKHELFKK-QGIPGPKPLPFLGTVL----------NYYKG 56

  Fly    87 MQKL-----------WGTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNKSHDYDYLHP--W 138
            :.|.           ||       ::.|..|.:.:.:|||::.:|..:.|...::..|: .|  .
Mouse    57 LWKFDMECYKKYGKTWG-------LFDGQTPLLAVTDPETIKNVLVKECFSVFTNRRDF-GPVGI 113

  Fly   139 LGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEV-GSEAFNLFPYVTL 202
            :.:.:..|.|.:|...|.:|:|.|....|.:...|..:...:|.:.|..:. ..:...:...:..
Mouse   114 MSKAISISKDDEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKGKPVTMKDVLGA 178

  Fly   203 CTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDF----IFS------LTA 257
            .::|::..|:.|..:.:.:|.|..:|:            :||..|:.||    :||      ||.
Mouse   179 YSMDVITSTSFGVNVDSLNNPEDPFVE------------KAKKLLRFDFFDPLLFSVVLFPFLTP 231

  Fly   258 EYKLHQSYI---NTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLID 319
            .|::....:   :::..|...|.|.:::.|                   |..:|.|:.||.|:::
Mouse   232 VYEMLNICMFPKDSIEFFKKFVDRMKESRL-------------------DSKQKHRVDFLQLMMN 277

  Fly   320 A---SKEGT---VLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGD 378
            :   ||:..   .||:.:|..:...|:|.|::|||:.:|:||..|..||:.|:::.:|:|...
Mouse   278 SHNNSKDKVSHKALSDMEITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEAL-- 340

  Fly   379 DKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRN 443
            ..:.|.|...:|:|.||:..:.::|||:|....:.|:..:||.:.|..:|.|:..:|.:||||.:
Mouse   341 PNKAPPTYDTVMEMEYLDMVLNETLRLYPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALHHD 405

  Fly   444 PRVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVD 508
            |:.:.:||:|.|:.|..||.....|:.|:||..|||||:|.:||::..|..::.:::.:..:...
Mouse   406 PQHWSEPEEFQPERFSKENKGSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCK 470

  Fly   509 RRE-DLTLLGELILRPKDGLRVKITPRD 535
            ..: .|.|..:.:|:|:..:.:|:.|||
Mouse   471 ETQIPLKLSRQGLLQPEKPIVLKVVPRD 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	124/505 (25%)
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	124/505 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810