Protein Alignment Cyp4c3 and Cyp26a1

DIOPT Version :10

• Sequence 1: NP_524598.1
• Gene: Cyp4c3 / 43663
• FlyBaseID: FBgn0015032
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_031837.2
• Gene: Cyp26a1 / 13082
• MGIID: 1096359
• Length: 497
• Species: Mus musculus
• Alignment Length: 553
• Identity: 132/553 - (23%)
• Similarity: 220/553 - (39%)
• Gaps: 117/553 - (21%)

  Fly    27 SPITVFLLGSILIFLV---------VYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDH----- 77
            |.:..|:| .:|:||.         |.::.||..   :...||....||.|..::|.:..
Mouse     9 SALCTFVL-PLLLFLAALKLWDLYCVSSRDRSCA---LPLPPGTMGFPFFGETLQMVLQRRKFLQ 69

  Fly    78 -----------DELFN----RVIGMQKLWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVN 127
                       ..||.    ||:|..       .:.|:..|....|.:..|.:|..|
Mouse    70 MKRRKYGFIYKTHLFGRPTVRVMGAD-------NVRRILLGEHRLVSVHWPASVRTI-------- 119

  Fly   128 KSHDYDYLHPWLGEGLLTST-DRKWHSRRKILTPAFHFKILDDFIDVFNEQ-SAVLARKLAVEVG 190
                       ||.|.|::. |.....|:|::..||..:.|..::.|..|: |:.|.:.|:  .|
Mouse   120 -----------LGAGCLSNLHDSSHKQRKKVIMQAFSREALQCYVPVIAEEVSSCLEQWLS--CG 171

  Fly   191 SEAFNLFPYVTLCTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSL 255
            .....::|.|......|.....:|.........|.|.        .:|::.:.    .:..:|||
Mouse   172 ERGLLVYPEVKRLMFRIAMRILLGCEPGPAGGGEDEQ--------QLVEAFEE----MTRNLFSL 224

  Fly   256 TAEYKLHQSYINTLHGFSNMV--IRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLI 318
            ..:..           ||.:.  ::.|....|.::||.............|.|.|..   |.|||
Mouse   225 PIDVP-----------FSGLYRGVKARNLIHARIEENIRAKIRRLQATEPDGGCKDA---LQLLI 275

  Fly   319 DASKE-GTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDS---IFGDD 379
            :.|.| |..|..:.:::.....:|.||:||::|.:..:..||.:|...::|.||:.|   :...:
Mouse   276 EHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREEIKSKGLLCKSN 340

  Fly   380 KETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNP 444
            ::....|:.|..::|..|.||::|||.|.||...|:..:...:.|..:|.|...|......|...
Mouse   341 QDNKLDMETLEQLKYTGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVA 405

  Fly   445 RVFPKPEQFNPDNFL---PENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEA 506
            .:|...|:||||.|:   ||: |.|  |::|||..|.|:|:|::||        ..:|:.:.:|
Mouse   406 DIFTNKEEFNPDRFIVPHPED-ASR--FSFIPFGGGLRSCVGKEFA--------KILLKIFTVE- 458

  Fly   507 VDRREDLTLL-GELILR------PKDGLRVKIT 532
            :.|..|..|| |...::      |.|.|..:.|
Mouse   459 LARHCDWQLLNGPPTMKTSPTVYPVDNLPARFT 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	CYP4V-like	96..529	CDD:410753	111/450 (25%)
Cyp26a1	NP_031837.2	CYP26A1	55..490	CDD:410731	118/500 (24%)