Protein Alignment Cyp4c3 and Cyp19a1

DIOPT Version :9

• Sequence 1: NP_524598.1
• Gene: Cyp4c3 / 43663
• FlyBaseID: FBgn0015032
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_001335100.1
• Gene: Cyp19a1 / 13075
• MGIID: 88587
• Length: 503
• Species: Mus musculus
• Alignment Length: 559
• Identity: 119/559 - (21%)
• Similarity: 241/559 - (43%)
• Gaps: 104/559 - (18%)

  Fly     6 ITSLMAESILLSKVGQVISGYSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNA 70
            :|.::.|::.:|.:        |: :.::|   :.|:::|...|      ..||||.....:|..
Mouse    13 VTIMVPETVTVSAM--------PL-LLIMG---LLLLIWNCESS------SSIPGPGYCLGIGPL 59

  Fly    71 IEMNVDHDELFNRVIG-----MQKLWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNK-- 128
            |    .|.......||     ..|::|.   ..|||......:::.:..::..::....::::
Mouse    60 I----SHGRFLWMGIGSACNYYNKMYGE---FMRVWISGEETLIISKSSSMFHVMKHSHYISRFG 117

  Fly   129 ---------SHDYDYLHPWLGEGLLTSTDRK-WHSRRKILTPAFHFKILDDFIDVFNEQSAVLAR 183
                     .|:         .|::.:.:.. |.:.|.....|.....|...::|     .|.:.
Mouse   118 SKRGLQCIGMHE---------NGIIFNNNPSLWRTIRPFFMKALTGPGLVRMVEV-----CVESI 168

  Fly   184 KLAVEVGSEAFNLFPYVTLCTL--DIVCETA----MGRRIYAQSNSESEYVKAVYGIGSIVQSRQ 242
            |..::...|..:...||.:.||  .|:.:|:    :|..:     .||..||.:.|..:..|:
Mouse   169 KQHLDRLGEVTDTSGYVDVLTLMRHIMLDTSNMLFLGIPL-----DESAIVKKIQGYFNAWQA-- 226

  Fly   243 AKIWLQSDFIFSLTAEYKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGK 307
              :.::.:..|.::..|:.::..:..|           |.|:|:|.|...:..:.|....|
Mouse   227 --LLIKPNIFFKISWLYRKYERSVKDL-----------KDEIAVLVEKKRHKVSTAEKLED---- 274

  Fly   308 KKRLAFLDLLIDASKEGTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEEL 372
              .:.|...||.|.:.|. |:.|::.:.:...:....||.|..:.:.|.|:..:||.:..:::|:
Mouse   275 --CMDFATDLIFAERRGD-LTKENVNQCILEMLIAAPDTMSVTLYFMLLLVAEYPEVEAAILKEI 336

  Fly   373 DSIFGDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMT 437
            .::.||   ....::::.:::.:|..|.:|:|..|.|.::.|...||..|.|..|..||..|:..
Mouse   337 HTVVGD---RDIKIEDIQNLKVVENFINESMRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNI 398

  Fly   438 YALHRNPRVFPKPEQFNPDNFLPENCAGRHPFAYI-PFSAGPRNCIGQKFAILEEKAVISTVLRK 501
            ..:|| ...||||.:|..:|| .:|.    |:.|. ||..|||.|.|:..|::..|.|:.|:||:
Mouse   399 GRMHR-LEYFPKPNEFTLENF-EKNV----PYRYFQPFGFGPRGCAGKYIAMVMMKVVLVTLLRR 457

  Fly   502 YKIEAVDRR--EDLTLLGELILRPKDG---LRVKITPRD 535
            ::::.:.:|  |::....:|.|.|.:.   :.:..:||:
Mouse   458 FQVKTLQKRCIENIPKKNDLSLHPNEDRHLVEIIFSPRN 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	108/500 (22%)
Cyp19a1	NP_001335100.1	p450	48..488	CDD:306555	108/496 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845016
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950