Protein Alignment Cyp4c3 and CYP4F22

DIOPT Version :10

• Sequence 1: NP_524598.1
• Gene: Cyp4c3 / 43663
• FlyBaseID: FBgn0015032
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_775754.2
• Gene: CYP4F22 / 126410
• HGNCID: 26820
• Length: 531
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 183/550 - (33%)
• Similarity: 294/550 - (53%)
• Gaps: 49/550 - (8%)

  Fly     6 ITSLMAESILLSKVGQVISGYSPITVFLLGSILIFLVVYNKRRSRLVK--YI-----EKIPGPAA 63
            ||..:...:.|.|....|...|.:.:||    |.||.....|..||.:  ||     ...|.|..
Human     4 ITDRLLHLLGLEKTAFRIYAVSTLLLFL----LFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPR 64

  Fly    64 MPFLGNAIEMNVDHDELFNRVIGMQ---KLWGTRIGINRVWQG-TAPRVLLFEPETVEPILNSQK 124
            ..:|...:.|.:.::      .|:|   |:......:..||.| ..|.::|..|:.::|:|.:..
Human    65 RNWLLGHLGMYLPNE------AGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASA 123

  Fly   125 FVNKSHD--YDYLHPWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLA---RK 184
            .:....|  |.:|.||||:|||.|...||...|::|||||||.||..::.:||:.:.::.   |.
Human   124 AIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRH 188

  Fly   185 LAVEVGSEAFNLFPYVTLCTLDIVCETAMGRRIYA-QSNSE---SEYVKAVYGIGSIVQSRQAKI 245
            || |..:.:.::|.:::|.|||     ::.:.::: .||.:   |:|:.|:..:.::...||.::
Human   189 LA-EGSAVSLDMFEHISLMTLD-----SLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRL 247

  Fly   246 WLQSDFIFSLTAEYKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKR 310
            ....|||:..:|:.:..:...:.:|.|:..||:||:..|          .....:|:....:.|.
Human   248 HHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRAL----------RQQGAEAWLKAKQGKT 302

  Fly   311 LAFLD-LLIDASKEGTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDS 374
            |.|:| ||:...::|..||:||||.|.||||||||||||:.|||.||.|..:|||||:..||:..
Human   303 LDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQE 367

  Fly   375 IFGDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTY 438
            :....:.......:|..:.:...|||:|||.:|.|.:::|...||:.: .|:|:|.|...::..|
Human   368 VMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIY 432

  Fly   439 ALHRNPRVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYK 503
            ..|.||.|:|..:.:||..|.|:|...|.|.||:||||||||||||.||:.|.:.|::..|.:::
Human   433 GTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFR 497

  Fly   504 IEAVDRREDLTLLGELILRPKDGLRVKITP 533
            : :|||...:....|||||.::||.:|:.|
Human   498 L-SVDRTRKVRRKPELILRTENGLWLKVEP 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	CYP4V-like	96..529	CDD:410753	158/444 (36%)
CYP4F22	NP_775754.2	CYP4F	82..523	CDD:410772	160/457 (35%)