DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4c3 and cyp4f3

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001083010.1	Gene:	cyp4f3 / 100037390	ZFINID:	ZDB-GENE-070410-108	Length:	511	Species:	Danio rerio

Alignment Length:	531	Identity:	150/531 - (28%)
Similarity:	261/531 - (49%)	Gaps:	56/531 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GQVISGYSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDHDELFNRV 84
            |..::|...::|..|...|:..::.|:|..|.                       .:...|.|.:
Zfish     4 GLSVTGILALSVAALLCALVTRIIINRRALRC-----------------------FNQPPLRNWI 45

  Fly    85 IGMQKLWG-TRIGINRV------------WQGTAP---RVLLFEPETVEPILNSQKFVNKSHD-- 131
            :|...|.| ...|:.||            | ...|   .|.||.|:.:..:|.:...:.....
Zfish    46 MGHMGLMGHNEEGLQRVDDLVCKYGHSCSW-FLGPFYNMVRLFHPDYIRSLLTASASITLKDRIF 109

  Fly   132 YDYLHPWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLA---RKLAVEVGSEA 193
            |.::.||||..||..:.::|...|::|||||||.||..::.:||:.:.::.   |:|..: |..:
Zfish   110 YGFMKPWLGNCLLLQSGQEWSRHRRLLTPAFHFDILKKYVHIFNQSTNIMHDEWRRLLAK-GEHS 173

  Fly   194 FNLFPYVTLCTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAE 258
            .::|..::..|||.:.:.......::|.... :|:.|:..:..::..||..:....|:::..:|:
Zfish   174 VDMFEQISSLTLDSLLKCTFSCDTHSQEKPR-QYISAILDLSRLLVQRQHYLPYHWDWLYWRSAQ 237

  Fly   259 YKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKE 323
            .:..|.....:|.|:..:::||:.:|     :..::..:.|:......|:|....:|||:.|..:
Zfish   238 GRRFQQACAVVHQFTADIVQERRTQL-----DQQSDPESHPENTGRYRKRKNTDLIDLLLLAKDD 297

  Fly   324 -GTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMK 387
             |..|:||:|:...|.|||.|||||::|:||..:.|..:.:||||...|:..:..|........:
Zfish   298 KGEGLTNEEIKAHADMFMFAGHDTTASALSWIFYNLAMNQDYQERCRAEVRDLLADRDTHTIGWE 362

  Fly   388 NLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNIGGK-IVPAGTQAIIMTYALHRNPRVFPKPE 451
            :|..:.:...|||:||||...|..:.|...:::...|. ::|.|...:|..|.:||||:|:|.|.
Zfish   363 DLSQLTFTTMCIKESLRLHSPVLALTRYYSQNMKTPGDCVIPHGCLCLISIYGVHRNPQVWPDPL 427

  Fly   452 QFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLL 516
            .|:|..|.|.|...|.|.|:|||||||||||||.||:.|.|.|::..|.::||  :...:.:..|
Zfish   428 VFDPTRFDPHNSDSRSPHAFIPFSAGPRNCIGQNFAMAEMKVVVALTLARFKI--LPGPKPVRRL 490

  Fly   517 GELILRPKDGL 527
            .:|:||.:.|:
Zfish   491 YQLVLRAEGGM 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	142/492 (29%)
cyp4f3	NP_001083010.1	p450	38..503	CDD:278495	142/474 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920