DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sap-r and PSAPL1

DIOPT Version :9

Sequence 1:	NP_524597.1	Gene:	Sap-r / 43662	FlyBaseID:	FBgn0000416	Length:	953	Species:	Drosophila melanogaster
Sequence 2:	NP_001078851.1	Gene:	PSAPL1 / 768239	HGNCID:	33131	Length:	521	Species:	Homo sapiens

Alignment Length:	691	Identity:	130/691 - (18%)
Similarity:	222/691 - (32%)	Gaps:	189/691 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLAVLALCCAFGVFAAATPLLGSSKCTWGPSYWCGNFSNSKECRATRHCIQTVWETQKVPVDTDS 70
            |.|:|.|....|. ..|:|..|..:|..|.:.||.:...:..|.|..:|...||..   |.....
Human     2 LCALLLLPSLLGA-TRASPTSGPQECAKGSTVWCQDLQTAARCGAVGYCQGAVWNK---PTAKSL 62

  Fly    71 ICTICKDMVTQARDQLKSNQTEEELKEVFEGSCKLIPIKPIQKECIKVADDFLPELVEAL--ASQ 133
            .|.:|:|:...|.:.|..:.||.::..:...:|:.:|.:.....|..:.|.....::..|  |..
Human    63 PCDVCQDIAAAAGNGLNPDATESDILALVMKTCEWLPSQESSAGCKWMVDAHSSAILSMLRGAPD 127

  Fly   134 MNPDQVCSVAGLCNSARIDELYKNGIQAGLDGTVQNEDDSSEETELAMQPNQLSCGNCNLLSRLM 198
            ..|.|||:...||                                   :|.|........||
Human   128 SAPAQVCTALSLC-----------------------------------EPLQRHLATLRPLS--- 154

  Fly   199 HSKFAATDRDDMVETMLHMCGSLSSFSDACANIVLTYFNDIYDHVSKHLTTDAVCHVSGVCASRY 263
                    ::|..|.:          :...||..||:
Human   155 --------KEDTFEAV----------APFMANGPLTF---------------------------- 173

  Fly   264 HQHEEEKQPQEALVALDAGDDIPCELCEQLVKHLRDVLVANTTETEFKQVMEGFCKQSKGFKDEC 328
               ...:.|:.||          |:.|.:.|..|::.:.:|.|..:. .:.|.......|....|
Human   174 ---HPRQAPEGAL----------CQDCVRQVSRLQEAVRSNLTLADL-NIQEQCESLGPGLAVLC 224

  Fly   329 LSIVDQYYHVIYETLVSKLDANGACCMIGICQKNSA-SSMKDVPIMPLLPVIEPAQVKITIEKLE 392
            .:.:.|:: |..:..:..|.....|...|.|::..| :.:..|..|..:|.:|
Human   225 KNYLFQFF-VPADQALRLLPPQELCRKGGFCEELGAPARLTQVVAMDGVPSLE------------ 276

  Fly   393 KHEKKQLGASEPKFSQQEILDMQLPIDHLMGAANPGALVEGGELCTLCEYMLHFIQETLATPSTD 457
                  ||....:...|                     ::.|..|.:|..::..:...|.:.|::
Human   277 ------LGLPRKQSEMQ---------------------MKAGVTCEVCMNVVQKLDHWLMSNSSE 314

  Fly   458 DEIKHTVENICAKLPSGVAGQCRNFVEMYGDAVIALLVQGLNPRDVCPLMQMCPKNLPKK--EDV 520
            ..|.|.:|.:|:.:|:.:..:|...|:.|..:::.|:.: :.|..||..:::|......:  .|.
Human   315 LMITHALERVCSVMPASITKECIILVDTYSPSLVQLVAK-ITPEKVCKFIRLCGNRRRARAVHDA 378

  Fly   521 EVFNPQPASD-EQDPPTCPLCLFAVEQAQMKIRDNKSKDNIKKVLNGLCSHLPNEIKEECVDFVN 584
            ....|.|..| |.....|..|...:..:...:....:|.:|.....|.||.||.....:|..||.
Human   379 YAIVPSPEWDAENQGSFCNGCKRLLTVSSHNLESKSTKRDILVAFKGGCSILPLPYMIQCKHFVT 443

  Fly   585 TYSNELIDMLITDFKPQEICVQLKLC--PKTTYALWDLRISLEDDVDGEDKSSSEEISFNDIESL 647
            .|...||:.|.....|..:|.::..|  |:|...             |.|
Human   444 QYEPVLIESLKDMMDPVAVCKKVGACHGPRTPLL-------------GTD--------------- 480

  Fly   648 EELPPQLAFDPGF-----TAAPNCLICEELVKTLEKRMGKH 683
                 |.|..|.|     .||..|...:...|.:.|.|..|
Human   481 -----QCALGPSFWCRSQEAAKLCNAVQHCQKHVWKEMHLH 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sap-r	NP_524597.1	SapA	27..59	CDD:295328	8/31 (26%)
		SapB	70..146	CDD:214797	17/77 (22%)
		SapB_1	72..106	CDD:282970	8/33 (24%)
		SapB_2	115..146	CDD:281486	8/32 (25%)
		SapB	186..259	CDD:214797	8/72 (11%)
		SapB_2	228..259	CDD:281486	4/30 (13%)
		SapB	285..359	CDD:214797	14/73 (19%)
		SapB_1	287..320	CDD:282970	7/32 (22%)
		SapB_2	328..359	CDD:281486	6/30 (20%)
		SapB	436..510	CDD:214797	16/73 (22%)
		SapB_1	437..471	CDD:282970	8/33 (24%)
		SapB_2	479..510	CDD:281486	7/30 (23%)
		SapB	535..610	CDD:214797	18/74 (24%)
		SapB_1	537..571	CDD:282970	7/33 (21%)
		SapB_2	579..610	CDD:281486	9/30 (30%)
		SapB	666..739	CDD:214797	5/18 (28%)
		SapB_1	666..700	CDD:282970	5/18 (28%)
		SapB_2	708..739	CDD:281486
		SapB	775..849	CDD:214797
		SapB_1	777..811	CDD:282970
		SapB_2	819..849	CDD:281486
		SapB	859..938	CDD:214797
PSAPL1	NP_001078851.1	SapA	22..55	CDD:295328	9/32 (28%)
		SapB	62..140	CDD:214797	17/77 (22%)
		SapB	183..254	CDD:214797	15/82 (18%)
		SapB	293..366	CDD:214797	16/73 (22%)
		SapB_1	294..328	CDD:282970	8/33 (24%)
		SapB_2	336..366	CDD:281486	7/30 (23%)
		SapB	394..469	CDD:214797	18/74 (24%)
		SapB_2	438..469	CDD:281486	9/30 (30%)
		SapA	479..509	CDD:280378	9/49 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151495
Domainoid	1	1.000	48	1.000	Domainoid score	I11934
eggNOG	1	0.900	-	-		E1_KOG1340
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	164	1.000	Inparanoid score	I4201
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54430
OrthoDB	1	1.010	-	-		D277021at33208
OrthoFinder	1	1.000	-	-		FOG0004597
OrthoInspector	1	1.000	-	-		otm41626
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11480
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3212
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.870