DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sap-r and psap

DIOPT Version :9

Sequence 1:	NP_524597.1	Gene:	Sap-r / 43662	FlyBaseID:	FBgn0000416	Length:	953	Species:	Drosophila melanogaster
Sequence 2:	NP_571958.2	Gene:	psap / 140811	ZFINID:	ZDB-GENE-020108-1	Length:	522	Species:	Danio rerio

Alignment Length:	613	Identity:	148/613 - (24%)
Similarity:	244/613 - (39%)	Gaps:	146/613 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 AAATPLLGSSKCTWGPSYWCGNFSNSKECRATRHCIQTVW---ETQKVPVDTDSICTICKDMVTQ 81
            |.|:||||:.:|..||.|||.|...:..|.|.:||.|.||   :.:.||      |.:||:::..
Zfish    12 AVASPLLGTEQCARGPPYWCQNVKTASLCGAVQHCQQNVWNKPQMKTVP------CDLCKEVLVV 70

  Fly    82 ARDQLKSNQTEEELKEVFEGSCKLIPIKPIQKECIKVADDFLPELVEALASQM-NPDQVCSVAGL 145
            ....||.|.||.||....|.:|:|||.:.:..:|.::.|::.|.|:..:..:: :|..||...||
Zfish    71 VEQLLKDNVTESELLGYLEKACQLIPDEGLANQCKEIVDNYFPVLMGIIQGELDDPGVVCGALGL 135

  Fly   146 CNSARIDELYKNGIQAGLDGTVQNEDDSSEETELAMQPNQLSCGNCNLLSRLMHSKFAATDRDDM 210
            |                          .|::..||.             ::|..::....|.:..
Zfish   136 C--------------------------VSQQAALAK-------------AQLTSNEIPQVDLNQR 161

  Fly   211 VETMLHMCGSLSSFSDACANIVLTYFNDIYDHVSKHLTTDAVCHVSGVCASRYHQHEEEKQPQEA 275
            |...|             .||                            ....:..|:.:.|::
Zfish   162 VSPFL-------------LNI----------------------------PQLLYPEEKRETPKQ- 184

  Fly   276 LVALDAGDDIPCELCEQLVKHLRDVLVANTT--ETEFKQVMEGFCK-QSKGFKDECLSIVDQYYH 337
                 .||  .|:.|...:...:|....|::  .|...|| |..|: ...|..|.|...:.||..
Zfish   185 -----KGD--VCQDCVTFINDTQDEARVNSSFISTLIAQV-ENQCELLGPGMSDMCKEYISQYGP 241

  Fly   338 VIYETLVS-KLDANGACCMIGICQKNSASSMKDVPIMPLLPVIE-PAQVKITIEKLEKHEKKQLG 400
            ::::.|:| :......|...|.|    .:..|.||:..|||... ||.......|:||
Zfish   242 LVFQQLMSMEQQPKDICARAGFC----PTKQKSVPMEKLLPAKSIPAVKMFPAVKVEK------- 295

  Fly   401 ASEPKFSQQEILDMQLPIDHLMGAANPGALVEGGELCTLCEYMLHFIQETLATPSTDDEIKHTVE 465
               |..:        :|..:|:       .|.....|.:|||::..|:..:...:::.||...||
Zfish   296 ---PVAT--------MPAKNLV-------RVRDSPQCAICEYVMKEIENMIQDQTSEAEIVQAVE 342

  Fly   466 NICAKLPSGVAGQCRNFVEMYGDAVIALLVQGLNPRDVCPLMQMCPKNLPKKEDVEVFNPQPASD 530
            .:|..|||.:..||::.:|.||.|:|.||||..:|:.||..:.:|          ...:..|..|
Zfish   343 KVCNILPSTLTAQCKDLIETYGQAIIDLLVQEADPKTVCSFLALC----------SGVSHVPVMD 397

  Fly   531 EQDPPT---CPLCLFAVEQAQMKIRDNKSKDNIKKVLNGLCSHLPNEIKEECVDFVNTYSNELID 592
            :|....   |.:|..||......:..|.::..|::.:..:||.||:.:|:||...:..|...|:.
Zfish   398 KQHFAAGGFCDVCKMAVRYVDGILEQNATQSEIEEAVLKVCSFLPDAVKDECNQLIEQYEPLLVQ 462

  Fly   593 MLITDFKPQEICVQLKLCPKTTYALWDL 620
            :|:....|..:|::|..||:....|..|
Zfish   463 LLLQTLDPDFVCMKLGACPEAVQRLLGL 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sap-r	NP_524597.1	SapA	27..59	CDD:295328	13/31 (42%)
		SapB	70..146	CDD:214797	23/76 (30%)
		SapB_1	72..106	CDD:282970	12/33 (36%)
		SapB_2	115..146	CDD:281486	8/31 (26%)
		SapB	186..259	CDD:214797	6/72 (8%)
		SapB_2	228..259	CDD:281486	2/30 (7%)
		SapB	285..359	CDD:214797	18/77 (23%)
		SapB_1	287..320	CDD:282970	9/35 (26%)
		SapB_2	328..359	CDD:281486	7/31 (23%)
		SapB	436..510	CDD:214797	27/73 (37%)
		SapB_1	437..471	CDD:282970	10/33 (30%)
		SapB_2	479..510	CDD:281486	13/30 (43%)
		SapB	535..610	CDD:214797	19/77 (25%)
		SapB_1	537..571	CDD:282970	8/33 (24%)
		SapB_2	579..610	CDD:281486	7/30 (23%)
		SapB	666..739	CDD:214797
		SapB_1	666..700	CDD:282970
		SapB_2	708..739	CDD:281486
		SapB	775..849	CDD:214797
		SapB_1	777..811	CDD:282970
		SapB_2	819..849	CDD:281486
		SapB	859..938	CDD:214797
psap	NP_571958.2	SAPA	19..52	CDD:128465	14/32 (44%)
		SapB	60..136	CDD:214797	24/81 (30%)
		SapB_1	61..95	CDD:282970	12/33 (36%)
		SapB_2	104..136	CDD:281486	8/31 (26%)
		SapB	187..264	CDD:214797	19/79 (24%)
		SapB_2	232..264	CDD:281486	7/31 (23%)
		SapB	314..387	CDD:214797	27/72 (38%)
		SapB_1	314..348	CDD:282970	10/33 (30%)
		SapB_2	356..387	CDD:281486	13/30 (43%)
		SapB	406..480	CDD:214797	19/73 (26%)
		SapB_1	407..441	CDD:282970	8/33 (24%)
		SapA	491..520	CDD:280378	148/613 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	40	1.000	Domainoid score	I12528
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37680
Inparanoid	1	1.050	149	1.000	Inparanoid score	I4357
OMA	1	1.010	-	-		QHG54430
OrthoDB	1	1.010	-	-		D277021at33208
OrthoFinder	1	1.000	-	-		FOG0004597
OrthoInspector	1	1.000	-	-		oto41568
orthoMCL	1	0.900	-	-		OOG6_102385
Panther	1	1.100	-	-	O	PTHR11480
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3697
SonicParanoid	1	1.000	-	-		X3212
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010