DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sap-r and sftpbb

DIOPT Version :9

Sequence 1:	NP_524597.1	Gene:	Sap-r / 43662	FlyBaseID:	FBgn0000416	Length:	953	Species:	Drosophila melanogaster
Sequence 2:	NP_001164537.1	Gene:	sftpbb / 100001978	ZFINID:	ZDB-GENE-060526-155	Length:	317	Species:	Danio rerio

Alignment Length:	338	Identity:	81/338 - (23%)
Similarity:	133/338 - (39%)	Gaps:	61/338 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   524 NPQP--ASDEQDPPTCPLCLFAVEQAQMKIRDNKSKDNIKKVLNGLCSHLPNEIKEECVDFVNTY 586
            :|:|  .|.......|..|...|:.....:....|:..|:|.::..|...|  :...|:|...||
Zfish    25 DPEPRITSHTMMNGMCSDCNKIVQLLTEMLSHPDSQHLIEKAVDRFCDEHP--VIPLCMDGAKTY 87

  Fly   587 SNELIDMLITDF-----KPQEICVQLKLCPKTTYALWDLRISLEDDVDGEDKSSSE-EISFNDIE 645
                :.::|..|     :..::|..|.||.                |..|.||:|| :.|.|: :
Zfish    88 ----VHLIIRHFSAFTKENGDVCSMLGLCA----------------VQPERKSASELDFSLNE-Q 131

  Fly   646 SLEELPPQLAFDPGFTAAPNCLICEELVKTLEKRMGKHPTRDSIKHILEESCDRMRKPMNTKCHK 710
            .|....|.....|.....|.|..|...:||:|..:.|..|..:|:.:||:.|..:.:.....|:.
Zfish   132 GLIYTKPSRGTGPEVRINPICNFCLLFIKTVESLLPKEKTEAAIEELLEKICGYLPEHYEDTCNT 196

  Fly   711 VIDKYGDKIADLLLKEMDPKLICTELGMCILADLDDLEVDEALKYDVIALPRQDNKLSSSIKEPP 775
            .:..|..::.:|||..|.|..|||.||:|:|.:...:                  .||:|..:..
Zfish   197 FVKTYAKQLIELLLYSMPPHAICTALGLCLLPETPAM------------------ALSASQTDCD 243

  Fly   776 TC----VLCEFIMTKLDADLKNKTEQDDIKRAIEAVCNRLPATVRKQCDTFVDGYASAVLKLLSD 836
            :|    ||.:|.:.....|    |:..|:   :..:|:..|..: .||:.||..:...:||....
Zfish   244 SCKILAVLSQFHLGLNATD----TQTSDL---LNKICHLHPDAI-PQCEGFVKFHGHRLLKTDGK 300

  Fly   837 VPPKQVCQKLQLC 849
            .|....|.|..||
Zfish   301 HPLITACLKDDLC 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sap-r	NP_524597.1	SapA	27..59	CDD:295328
		SapB	70..146	CDD:214797
		SapB_1	72..106	CDD:282970
		SapB_2	115..146	CDD:281486
		SapB	186..259	CDD:214797
		SapB_2	228..259	CDD:281486
		SapB	285..359	CDD:214797
		SapB_1	287..320	CDD:282970
		SapB_2	328..359	CDD:281486
		SapB	436..510	CDD:214797
		SapB_1	437..471	CDD:282970
		SapB_2	479..510	CDD:281486
		SapB	535..610	CDD:214797	16/79 (20%)
		SapB_1	537..571	CDD:282970	7/33 (21%)
		SapB_2	579..610	CDD:281486	8/35 (23%)
		SapB	666..739	CDD:214797	23/72 (32%)
		SapB_1	666..700	CDD:282970	11/33 (33%)
		SapB_2	708..739	CDD:281486	12/30 (40%)
		SapB	775..849	CDD:214797	18/77 (23%)
		SapB_1	777..811	CDD:282970	8/37 (22%)
		SapB_2	819..849	CDD:281486	8/29 (28%)
		SapB	859..938	CDD:214797
sftpbb	NP_001164537.1	SapB	40..112	CDD:214797	16/77 (21%)
		SapB	150..225	CDD:214797	24/74 (32%)
		SapB_1	152..186	CDD:282970	11/33 (33%)
		SapB_2	194..225	CDD:281486	12/30 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580265
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1340
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D277021at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840