Protein Alignment CG12071 and ZNF594

DIOPT Version :10

• Sequence 1: NP_651832.3
• Gene: CG12071 / 43660
• FlyBaseID: FBgn0039808
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: NP_115919.1
• Gene: ZNF594 / 84622
• HGNCID: 29392
• Length: 807
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 108/558 - (19%)
• Similarity: 196/558 - (35%)
• Gaps: 142/558 - (25%)

  Fly    20 QQQMAQAAIQFKQQQTSQQ-QNSPTANNNNNSQNNGNMQQQQQQQQQQQQQQQQQQQQQHYAATI 83
            :::.|:||.:..|:|.:|: :...|:|:.:....  :.....:...:....|:...::.|.
Human    13 EKKSARAASEKLQRQITQECELVETSNSEDRLLK--HWVSPLKDAMRHLPSQESGIREMHI---- 71

  Fly    84 KVPQISSSNVAAAAAGESTFTVPDDGMGFEGGVRVLQSLGTWSAAEQLTYNIPKPNLIPFTEPYV 148
             :||       .|..||.       |.|...|.::|.:
Human    72 -IPQ-------KAIVGEI-------GHGCNEGEKILSA--------------------------- 94

  Fly   149 EGGSMHPASRLKALQQVQQASSGVRKTNPSKSTNKAFECTVCGKGLARKDKLTIHMRIHTGEKPY 213
             |.|.|   |.:...|..:..||:.:.....:.||.:||..|.|...|...|.||.|||||.|||
Human    95 -GESSH---RYEVSGQNFKQKSGLTEHQKIHNINKTYECKECEKTFNRSSNLIIHQRIHTGNKPY 155

  Fly   214 ICEVCNKAFARRDKLVIHMNKFKHVTPTNIAPLGKRLN---NMVKKKE-----QPDPPPEDNKQ- 269
            :|..|.|...:...|:||........|......||..|   |:|:.|:     .|....|..|.
Human   156 VCNECGKDSNQSSNLIIHQRIHTGKKPYICHECGKDFNQSSNLVRHKQIHSGGNPYECKECGKAF 220

  Fly   270 --SLELQLQQQAVQVAAQNIIVQSAQGAPTSIPGIIIPH--HQQQLSWTCELCGRMFSSRDEWSI 330
              |..|.|.|: :....:..:......|.:....:||.|  |..:..:.|..||:|||.
Human   221 KGSSNLVLHQR-IHSRGKPYLCNKCGKAFSQSTDLIIHHRIHTGEKPYECYDCGQMFSQ------ 278

  Fly   331 HAKSHLEYXQPERLVAESTKPAAAAAGVIAKTTSSNNSRNYQMDANQNQIQMEAQARKQKIIIQN 395
              .|||   .|.:.:....||                     :..|    :.|...|:...:.::
Human   279 --SSHL---VPHQRIHTGEKP---------------------LKCN----ECEKAFRQHSHLTEH 313

  Fly   396 QMILNASHQQQQQPQQHPQQQQHQQQQQQHVAHGKKAARKHQQ-HLQQQQQQ-----QQQQQQQQ 454
            |.:             |..::.::..:......|:.|..|||: |..::.::     .:.::.::
Human   314 QRL-------------HSGEKPYECHRCGKTFSGRTAFLKHQRLHAGEKIEECEKTFSKDEELRE 365

  Fly   455 QQQQQQTSAPMYNNNSSSNHNGNNQSQEVSVPVSHIIANSPTAATYMQAQLSEHASNMQHGMPIV 519
            :|:..|.....:.|....|..|.  |..:...|:| ....|..........::.:..::|..
Human   366 EQRIHQEEKAYWCNQCGRNFQGT--SDLIRHQVTH-TGEKPYECKECGKTFNQSSDLLRHHR--- 424

  Fly   520 TYNGNQYCVITRAPDLDVEAMQKPLDYGHAAGGATNII 557
            .::|.:.||.::.              |.:..|::::|
Human   425 IHSGEKPCVCSKC--------------GKSFRGSSDLI 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12071	NP_651832.3	zf-C2H2	185..207	CDD:395048	9/21 (43%)
		C2H2 Zn finger	187..207	CDD:275368	8/19 (42%)
		zf-H2C2_2	200..224	CDD:463886	14/23 (61%)
		C2H2 Zn finger	215..232	CDD:275368	5/16 (31%)
ZNF594	NP_115919.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		3/9 (33%)
		COG5048	96..518	CDD:227381	88/426 (21%)
		C2H2 Zn finger	105..121	CDD:275368	3/15 (20%)
		C2H2 Zn finger	129..149	CDD:275368	8/19 (42%)
		C2H2 Zn finger	157..177	CDD:275368	6/19 (32%)
		C2H2 Zn finger	185..205	CDD:275368	6/19 (32%)
		C2H2 Zn finger	213..233	CDD:275368	6/20 (30%)
		C2H2 Zn finger	241..261	CDD:275368	4/19 (21%)
		C2H2 Zn finger	269..289	CDD:275368	10/30 (33%)
		C2H2 Zn finger	297..317	CDD:275368	4/36 (11%)
		C2H2 Zn finger	325..345	CDD:275368	5/19 (26%)
		C2H2 Zn finger	351..370	CDD:275370	1/18 (6%)
		C2H2 Zn finger	378..398	CDD:275368	5/21 (24%)
		COG5048	402..791	CDD:227381	8/64 (13%)
		C2H2 Zn finger	406..426	CDD:275368	1/22 (5%)
		C2H2 Zn finger	434..454	CDD:275368	3/29 (10%)
		C2H2 Zn finger	462..482	CDD:275368
		C2H2 Zn finger	490..510	CDD:275368
		C2H2 Zn finger	518..538	CDD:275368
		C2H2 Zn finger	570..590	CDD:275368
		C2H2 Zn finger	598..618	CDD:275368
		C2H2 Zn finger	626..646	CDD:275368
		C2H2 Zn finger	654..674	CDD:275368
		C2H2 Zn finger	682..702	CDD:275368
		C2H2 Zn finger	710..730	CDD:275368
		C2H2 Zn finger	736..755	CDD:275368
		C2H2 Zn finger	763..783	CDD:275370