DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12071 and PRDM15

DIOPT Version :9

Sequence 1:NP_651832.3 Gene:CG12071 / 43660 FlyBaseID:FBgn0039808 Length:581 Species:Drosophila melanogaster
Sequence 2:XP_011527985.1 Gene:PRDM15 / 63977 HGNCID:13999 Length:1441 Species:Homo sapiens


Alignment Length:551 Identity:111/551 - (20%)
Similarity:187/551 - (33%) Gaps:144/551 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   130 QLTYNIPKPNLIPFTEPYVEGG-SMHPASRLKALQQVQQASSGVRKTN-PSKSTNKAFE-CTVCG 191
            |||:...|..|....|.:.|.| .....:|..||:....|...:.:.| |..:..|... |.:||
Human   932 QLTFGRGKEYLKHIMEVHKEKGYGCSICNRRFALKATYHAHMVIHRENLPDPNVQKYIHPCEICG 996

  Fly   192 KGLARKDKLTIHMRIHTGEKPYICEVCNKAFARRDKLVIHMNKFKHVTPTNIAPLGKRLNNMVKK 256
            :.......|..|..||||.|.:.||.|.|:|||:|.|..||....:|.....|..||.:.     
Human   997 RIFNSIGNLERHKLIHTGVKSHACEQCGKSFARKDMLKEHMRVHDNVREYLCAECGKGMK----- 1056

  Fly   257 KEQPDPPPEDNKQSL--ELQLQQQAVQVAAQNIIVQSAQGAPTSIPGIIIPH---HQQQLSWTCE 316
                      .|.:|  .::|.:...:...:....:.||...      ::.|   |.....:.||
Human  1057 ----------TKHALRHHMKLHKGIKEYECKECHRRFAQKVN------MLKHCKRHTGIKDFMCE 1105

  Fly   317 LCGRMFSSRDEWSIHAKSHLEYXQPERLVAESTKPAAAAAGVIAKTTSSNNSRNYQMDANQNQIQ 381
            |||:.||.|:....|...|.                     |..:.|.|...:.|   ..:..:|
Human  1106 LCGKTFSERNTMETHKLIHT---------------------VGKQWTCSVCDKKY---VTEYMLQ 1146

  Fly   382 MEAQARKQKIIIQNQMILN---------ASHQQQQQPQ---------QH-PQQ-----------Q 416
            ...|....|:..|:..:..         :.|.:::.|:         .| |:.           |
Human  1147 KHVQLTHDKVEAQSCQLCGTKVSTRASMSRHMRRKHPEVLAVRIDDLDHLPETTTIDASSIGIVQ 1211

  Fly   417 QHQQQQQQHVA---HGKKAARKHQQHLQQQQQ------QQQQQQQQQQQQQQQTSAPMYNNNSS- 471
            .....:|:.:|   |||.|.|.|::..:.:::      :.....:..:::.:.|.:.....||: 
Human  1212 PELTLEQEDLAEGKHGKAAKRSHKRKQKPEEEAGAPVPEDATFSEYSEKETEFTGSVGDETNSAV 1276

  Fly   472 ----------SNHNGNNQSQEV---SVPVSHIIANSPTAATYMQAQLSEHASNMQHGMPI----- 518
                      .:.|....|..|   ::.|:.|...:.|..|.:|.....|.:..:..:.:     
Human  1277 QSIQQVVVTLGDPNVTTPSSSVGLTNITVTPITTAAATQFTNLQPVAVGHLTTPERQLQLDNSIL 1341

  Fly   519 -VTYN--GNQYCVITRAPDLDVEAM---QKPLDYGHAAGGATNIIVMSPM--------------- 562
             ||::  .....:..|..|:.:...   ..|....|.....|.:..::|:               
Human  1342 TVTFDTVSGSAMLHNRQNDVQIHPQPEASNPQSVAHFINLTTLVNSITPLGSQLSDQHPLTWRAV 1406

  Fly   563 ---QLLPPQQQQQQPQQ---------QQQQQ 581
               .:|||.|.|..|||         |||||
Human  1407 PQTDVLPPSQPQAPPQQAAQPQVQAEQQQQQ 1437

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12071NP_651832.3 zf-C2H2 185..207 CDD:278523 5/22 (23%)
C2H2 Zn finger 187..207 CDD:275368 5/19 (26%)
zf-H2C2_2 200..224 CDD:290200 12/23 (52%)
C2H2 Zn finger 215..232 CDD:275368 9/16 (56%)
PRDM15XP_011527985.1 SET 349..465 CDD:214614
GAGA_bind <515..>580 CDD:283799
COG5048 663..1125 CDD:227381 56/213 (26%)
zf-C2H2 672..694 CDD:278523
C2H2 Zn finger 674..694 CDD:275368
C2H2 Zn finger 701..722 CDD:275368
C2H2 Zn finger 735..751 CDD:275368
C2H2 Zn finger 789..809 CDD:275368
C2H2 Zn finger 838..858 CDD:275368
C2H2 Zn finger 865..885 CDD:275368
C2H2 Zn finger 928..949 CDD:275370 6/16 (38%)
C2H2 Zn finger 956..976 CDD:275368 4/19 (21%)
C2H2 Zn finger 992..1012 CDD:275368 5/19 (26%)
zf-H2C2_2 1004..1029 CDD:290200 12/24 (50%)
C2H2 Zn finger 1020..1040 CDD:275368 11/19 (58%)
C2H2 Zn finger 1048..1068 CDD:275368 5/34 (15%)
zf-H2C2_2 1060..1085 CDD:290200 2/24 (8%)
C2H2 Zn finger 1076..1096 CDD:275368 3/25 (12%)
C2H2 Zn finger 1104..1124 CDD:275368 9/19 (47%)
C2H2 Zn finger 1132..1153 CDD:275368 4/23 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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