Protein Alignment CG12071 and ZNF418

DIOPT Version :10

• Sequence 1: NP_651832.3
• Gene: CG12071 / 43660
• FlyBaseID: FBgn0039808
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: NP_001303956.1
• Gene: ZNF418 / 147686
• HGNCID: 20647
• Length: 697
• Species: Homo sapiens
• Alignment Length: 296
• Identity: 60/296 - (20%)
• Similarity: 110/296 - (37%)
• Gaps: 75/296 - (25%)

  Fly   157 SRLKALQQVQQASSGVRKTNPSKSTNKAFECTVCGKGLARKDKLTIHMRIHTGEKPYICEVCNKA 221
            |:..::...|:..:|.|          .:||..|||..:.|..|..|.|:|||::||.|..|.|:
Human   261 SKYDSVSNHQRVHTGKR----------PYECGECGKSFSHKGSLVQHQRVHTGKRPYECGECGKS 315

  Fly   222 FARRDKLVIHMNKFKHVTPTNIAPLGKRLN---NMVKKK-----EQPDPPPEDNKQSLELQLQQQ 278
            |:.:..||.|........|......||..:   .::|.:     |:|....|..|...:
Human   316 FSHKGSLVQHQRVHTGERPYECGECGKSFSQNGTLIKHQRVHTGERPYECEECGKCFTQ------ 374

  Fly   279 AVQVAAQNIIVQSAQGAPTSIPGIIIPHHQQQLSWTCELCGRMFSSRDEWSIHAKSHLEYXQPER 343
                  :..::|..:|            |..:..:.||.||:.||.:...:.|.:.|
Human   375 ------KGNLIQHQRG------------HTSERPYECEECGKCFSQKGTLTEHHRVH-------- 413

  Fly   344 LVAESTKPAAAAAGVIAKTTS-SNNSRNYQM-DANQNQIQM----EAQARKQKIIIQNQMILNAS 402
                 |:......|...|:.| ..:.||:|. ...:...:.    ::.:||..:|
Human   414 -----TRERPYECGECGKSFSRKGHLRNHQRGHTGERPYECGECGKSFSRKGNLI---------- 463

  Fly   403 HQQQQQPQQHPQQQQHQQQQQQHVAHGKKAARKHQQ 438
                |..:.|..::.::.::.:.:..||....:||:
Human   464 ----QHQRSHTGERPYECRECRKLFRGKSHLIEHQR 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12071	NP_651832.3	zf-C2H2	185..207	CDD:395048	9/21 (43%)
		C2H2 Zn finger	187..207	CDD:275368	8/19 (42%)
		zf-H2C2_2	200..224	CDD:463886	12/23 (52%)
		C2H2 Zn finger	215..232	CDD:275368	6/16 (38%)
ZNF418	NP_001303956.1	KRAB	26..66	CDD:460171
		C2H2 Zn finger	105..125	CDD:275368
		C2H2 Zn finger	253..273	CDD:275368	2/11 (18%)
		C2H2 Zn finger	281..301	CDD:275368	8/19 (42%)
		COG5048	304..692	CDD:227381	44/243 (18%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		C2H2 Zn finger	337..357	CDD:275368	3/19 (16%)
		C2H2 Zn finger	365..385	CDD:275368	4/43 (9%)
		C2H2 Zn finger	393..413	CDD:275368	7/19 (37%)
		C2H2 Zn finger	421..441	CDD:275368	6/19 (32%)
		C2H2 Zn finger	449..469	CDD:275368	4/33 (12%)
		C2H2 Zn finger	477..497	CDD:275368	4/19 (21%)
		C2H2 Zn finger	505..525	CDD:275368
		C2H2 Zn finger	533..553	CDD:275368
		C2H2 Zn finger	561..581	CDD:275368
		C2H2 Zn finger	589..606	CDD:275368
		C2H2 Zn finger	614..634	CDD:275368
		C2H2 Zn finger	642..662	CDD:275368
		C2H2 Zn finger	670..690	CDD:275368