Protein Alignment tll and NR1H4

DIOPT Version :9

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_001193922.1
• Gene: NR1H4 / 9971
• HGNCID: 7967
• Length: 486
• Species: Homo sapiens
• Alignment Length: 411
• Identity: 91/411 - (22%)
• Similarity: 146/411 - (35%)
• Gaps: 108/411 - (26%)

  Fly    23 AASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQ 87
            |::.||.....|.||.|.:||.||....|:||.|||:|||.::..|.||:  .|.||:|...|.:
Human   126 ASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKN--GGNCVMDMYMRRK 188

  Fly    88 CRACRLRKCFEVGMNKDAVQ----HERGPRNSTLRRHMAMYKDAMMG----AGEMPQIPA----- 139
            |:.||||||.|:||..:.:.    .|...::..||:::..:.|..:.    ..::.|:.:
Human   189 CQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSC 253

  Fly   140 ----EILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLD-LSVPRVPHHPVHQ 199
                |:..:...|..|                                ::| .:..|:|....::
Human   254 REKTELTPDQQTLLHF--------------------------------IMDSYNKQRMPQEITNK 286

  Fly   200 GHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLL 264
            .....||   |..|.|.               :.|.|..|:...|.:.|.:..|..|...||:.|
Human   287 ILKEEFS---AEENFLI---------------LTEMATNHVQVLVEFTKKLPGFQTLDHEDQIAL 333

  Fly   265 LEESWKEFFILAMAQYL---MPMNFAQLLFVYESENANREIMGMVTREVHAFQEVLNQLCHLNID 326
            |:.|..|...|..|:..   :|...:.||   |....|..|.......:.:|.:.:.:   |.:.
Human   334 LKGSAVEAMFLRSAEIFNKKLPSGHSDLL---EERIRNSGISDEYITPMFSFYKSIGE---LKMT 392

  Fly   327 STEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSA 391
            ..||..|.||.:.                             |.:.:.:.:...|..:.......
Human   393 QEEYALLTAIVIL-----------------------------SPDRQYIKDREAVEKLQEPLLDV 428

  Fly   392 LHNYIQRTHPSQPMRFQTLLG 412
            |....:...|..|..|..|||
Human   429 LQKLCKIHQPENPQHFACLLG 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	38/95 (40%)
		NR_LBD	215..436	CDD:416257	38/201 (19%)
NR1H4	NP_001193922.1	NR_DBD_FXR	134..221	CDD:143520	36/88 (41%)
		NR_LBD_Fxr	261..481	CDD:132734	47/274 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910