Protein Alignment tll and NR1I2

DIOPT Version :9

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_071285.1
• Gene: NR1I2 / 8856
• HGNCID: 7968
• Length: 473
• Species: Homo sapiens
• Alignment Length: 467
• Identity: 102/467 - (21%)
• Similarity: 167/467 - (35%)
• Gaps: 147/467 - (31%)

  Fly    34 CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFE 98
            |:||.|.::|.|:.:..|:||.|||:|:::|:.:..|..:| |.|.:.:..|.||:|||||||.|
Human    80 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRK-GACEITRKTRRQCQACRLRKCLE 143

  Fly    99 VGMNKDAVQHERG--PRNSTLRRHMAMYKD----AMMGAGEMPQIPAEILMNTAALT-------- 149
            .||.|:.:..:..  .|.:.::|..:....    .:.|..|..::....||:....|
Human   144 SGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHF 208

  Fly   150 ---GFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAV------LDLSVPRVP------------ 193
               ..|||......||:          :.|.|....|.      .||...:|.
Human   209 KNFRLPGVLSSGCELPE----------SLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWN 263

  Fly   194 -HHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKN-VNWIKSVRAFTEL 256
             ..|...|....||            .||         |:.:.:. ::||. :::.|.:..|.:|
Human   264 YKPPADSGGKEIFS------------LLP---------HMADMST-YMFKGIISFAKVISYFRDL 306

  Fly   257 PMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLLF--VYESENANRE---IMGMVTREVHAFQEV 316
            |:.||:.||:.:              .....||.|  |:.:|....|   :...:......||::
Human   307 PIEDQISLLKGA--------------AFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQL 357

  Fly   317 LNQ--------LCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESR 373
            |.:        |..|.:...||..::|||||....|
Human   358 LLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRP----------------------------- 393

  Fly   374 GLLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDIT 438
            |:|:...|..:.......|.:||:...|....||                     .|.|.:..:|
Human   394 GVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRF---------------------LFLKIMAMLT 437

  Fly   439 IVRLISDMYSQR 450
            .:|.|:..::||
Human   438 ELRSINAQHTQR 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	33/84 (39%)
		NR_LBD	215..436	CDD:416257	43/234 (18%)
NR1I2	NP_071285.1	NR_DBD_PXR	79..166	CDD:143536	33/86 (38%)
		NR_LBD_PXR_like	182..467	CDD:132732	67/364 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910