Protein Alignment tll and Nr1i2

DIOPT Version :9

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_443212.1
• Gene: Nr1i2 / 84385
• RGDID: 69057
• Length: 431
• Species: Rattus norvegicus
• Alignment Length: 489
• Identity: 100/489 - (20%)
• Similarity: 175/489 - (35%)
• Gaps: 156/489 - (31%)

  Fly    12 DQKYNSVRLSPAASSRILYHVP------------CKVCRDHSSGKHYGIYACDGCAGFFKRSIRR 64
            ::::|.|.|.....:..:...|            |:||.|.::|.|:.:..|:||.|||:|:::|
  Rat     4 EERWNHVGLVQREEADSVLEEPINVDEEDGGLQICRVCGDKANGYHFNVMTCEGCKGFFRRAMKR 68

  Fly    65 SRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERG--PRNSTLRRH------- 120
            :.:..|..:| |.|.:.:..|.||:|||||||.|.||.|:.:..:..  .|.:.::|.
  Rat    69 NVRLRCPFRK-GTCEITRKTRRQCQACRLRKCLESGMKKEMIMSDAAVEQRRALIKRKKREKIEA 132

  Fly   121 ------------------------------MAMYKDAMMGA-----GEMPQI-PAEILMNTAALT 149
                                          .:.:||..:.|     .|:|:: .|.:|.:.|..:
  Rat   133 PPPGGQGLTEEQQALIQELMDAQMQTFDTTFSHFKDFRLPAVFHSDCELPEVLQASLLEDPATWS 197

  Fly   150 GFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNA 214
            ......:||....|..| ....:..:|||..:..  ...:|.:||          .:..:.||
  Rat   198 QIMKDSVPMKISVQLRG-EDGSIWNYQPPSKSDG--KEIIPLLPH----------LADVSTYM-- 247

  Fly   215 LATRALPPTPPLMAAEHIKETAAEHLFKNV-NWIKSVRAFTELPMPDQLLLLEESWKEFFILAMA 278
                                      ||.| |:.|.:..|.|||:.||:.||:.:..|..||...
  Rat   248 --------------------------FKGVINFAKVISHFRELPIEDQISLLKGATFEMCILRFN 286

  Fly   279 QYL----MPMNFAQLLFVYESENANREIMGMVTREVHAFQEVL--------NQLCHLNIDSTEYE 331
            ...    ......:|.:.:|..|.             .||::|        ..|..|.:...||.
  Rat   287 TMFDTETGTWECGRLAYCFEDPNG-------------GFQKLLLDPLMKFHCMLKKLQLREEEYV 338

  Fly   332 CLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYI 396
            .::|||||....|                             |:::...|..:.......|..||
  Rat   339 LMQAISLFSPDRP-----------------------------GVVQRSVVDQLQERFALTLKAYI 374

  Fly   397 Q--RTHPSQPMRFQTLLGVVQLMHKVSSFTIEEL 428
            :  |.:|:....|..::.|:..:..:::...::|
  Rat   375 ECSRPYPAHRFLFLKIMAVLTELRSINAQQTQQL 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	34/105 (32%)
		NR_LBD	215..436	CDD:416257	42/229 (18%)
Nr1i2	NP_443212.1	NR_DBD_like	37..124	CDD:413390	33/87 (38%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250	63..89		6/26 (23%)
		Hinge	105..142		3/36 (8%)
		NR_LBD	140..425	CDD:416257	62/352 (18%)
		Hyperforin binding, agonist. /evidence=ECO:0000250|UniProtKB:O75469	282..285		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910