DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and NR0B2

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_068804.1	Gene:	NR0B2 / 8431	HGNCID:	7961	Length:	257	Species:	Homo sapiens

Alignment Length:	304	Identity:	64/304 - (21%)
Similarity:	102/304 - (33%)	Gaps:	80/304 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 GHHPAHMAAFQPPPSAAAVLDLSVPRVP----------HHPVHQGHHGFFSPTAAYMNALATRAL 220
            |..|...||.: |....|:|..|:..||          |.||.
Human     7 GACPCQGAASR-PAILYALLSSSLKAVPRPRSRCLCRQHRPVQ---------------------- 48

  Fly   221 PPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMN 285
                 |.|.......|.:.|.|.|.:::::.:|.:||..||..||:..|...|:|.:||..:...
Human    49 -----LCAPHRTCREALDVLAKTVAFLRNLPSFWQLPPQDQRRLLQGCWGPLFLLGLAQDAVTFE 108

  Fly   286 FAQ----------LLFVYESENANREIMGMVTREVHAFQEV---LNQLCHLNIDSTEYECLRAIS 337
            .|:          ||....|...:.::.......:.|.|.:   |.....|.:...||.||:...
Human   109 VAEAPVPSILKKILLEEPSSSGGSGQLPDRPQPSLAAVQWLQCCLESFWSLELSPKEYACLKGTI 173

  Fly   338 LFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPS 402
            ||....|                             ||..:..:..:..:|...|...::...|:
Human   174 LFNPDVP-----------------------------GLQAASHIGHLQQEAHWVLCEVLEPWCPA 209

  Fly   403 QPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDM 446
            ...|...:|.....:..:.:..:.:||||..|||:.|..|:.||
Human   210 AQGRLTRVLLTASTLKSIPTSLLGDLFFRPIIGDVDIAGLLGDM 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	45/233 (19%)
NR0B2	NP_068804.1	NR_LBD_SHP	32..254	CDD:132763	56/278 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910