DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tll and Rxrg

DIOPT Version :9

Sequence 1:NP_524596.1 Gene:tll / 43656 FlyBaseID:FBgn0003720 Length:452 Species:Drosophila melanogaster
Sequence 2:XP_038947050.1 Gene:Rxrg / 83574 RGDID:620046 Length:464 Species:Rattus norvegicus


Alignment Length:456 Identity:121/456 - (26%)
Similarity:194/456 - (42%) Gaps:115/456 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MQSSE------GSPDMMDQKYNSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFK 59
            :.|||      |.|.:.:..|.|.  ||.:   ::.|: |.:|.|.|||||||:|:|:||.||||
  Rat   106 VSSSEDIKPLPGLPGIGNMNYPST--SPGS---LVKHI-CAICGDRSSGKHYGVYSCEGCKGFFK 164

  Fly    60 RSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMY 124
            |:||:...|.|:..|.  |::||..||:|:.||.:||..:||.::|||.||              
  Rat   165 RTIRKDLIYTCRDNKD--CLIDKRQRNRCQYCRYQKCLVMGMKREAVQEER-------------- 213

  Fly   125 KDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSV 189
                ..:.|..:..||     .|.||...:|:      :|.  ..|.:|.   .|...:..|:||
  Rat   214 ----QRSRERAESEAE-----CASTGHEDMPV------ERI--LEAELAV---EPKTESYGDMSV 258

  Fly   190 PRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFT 254
            ....:.||                                .:|...|.:.||..|.|.|.:..|:
  Rat   259 ESSTNDPV--------------------------------TNICHAADKQLFTLVEWAKRIPHFS 291

  Fly   255 ELPMPDQLLLLEESWKEFFILAMAQYLMPMN----FAQLLFVYESENANREIMGMVTREVHAFQE 315
            :|.:.||::||...|.|..|.:.:...:.:.    .|..|.|:.| :|:...:|.:. :.....|
  Rat   292 DLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRS-SAHSAGVGSIF-DSRVLTE 354

  Fly   316 VLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGK 380
            :::::..:.:|.:|..|||||.||                             :.:::||....:
  Rat   355 LVSKMKDMRMDKSELGCLRAIVLF-----------------------------NPDAKGLSNPSE 390

  Fly   381 VAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISD 445
            |..:.....:.|..|.::.:|.||.||..||..:..:..:....:|.|||.|.|||..|...:.:
  Rat   391 VETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLME 455

  Fly   446 M 446
            |
  Rat   456 M 456

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tllNP_524596.1 NR_DBD_TLX 25..117 CDD:143537 42/91 (46%)
NR_LBD 215..436 CDD:416257 50/224 (22%)
RxrgXP_038947050.1 Nuc_recep-AF1 25..133 CDD:403126 9/28 (32%)
NR_DBD_RXR 137..213 CDD:143514 40/78 (51%)
NR_LBD_RXR_like 233..442 CDD:132741 58/282 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X118
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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