DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tll and Thra

DIOPT Version :9

Sequence 1:NP_524596.1 Gene:tll / 43656 FlyBaseID:FBgn0003720 Length:452 Species:Drosophila melanogaster
Sequence 2:NP_112396.2 Gene:Thra / 81812 RGDID:3857 Length:492 Species:Rattus norvegicus


Alignment Length:497 Identity:114/497 - (22%)
Similarity:169/497 - (34%) Gaps:142/497 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 QSSEGSPDMMDQKYNSVRLSPAASSRILYHVP--------CKVCRDHSSGKHYGIYACDGCAGFF 58
            ::|..|||...::.|.  ..|..||...| :|        |.||.|.::|.||....|:||.|||
  Rat    16 ENSARSPDGKRKRKNG--QCPLKSSMSGY-IPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFF 77

  Fly    59 KRSIRRSRQ--YVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAV--------QHERGPR 113
            :|:|:::..  |.||  ....||:||..||||:.||.:||..|||..|.|        :.:...:
  Rat    78 RRTIQKNLHPTYSCK--YDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQ 140

  Fly   114 NSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPP 178
            |...||...|.:                                  .|.||.          :|.
  Rat   141 NRERRRKEEMIR----------------------------------SLQQRP----------EPT 161

  Fly   179 PSAAAVLDLSVPRVPHHPVH-QGHH----GFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAE 238
            |....::.::..  .|...: ||.|    ..|.|.....:.:.:........|.|.....:....
  Rat   162 PEEWDLIHVATE--AHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITP 224

  Fly   239 HLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLL---FVYESENANR 300
            .:.:.|::.|.:..|:|||..||::||:....|...|..|....|.:....|   ...:.|....
  Rat   225 AITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKN 289

  Fly   301 EIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISL-------------FRKSP--------- 343
            ..:|:|:   .|..|:...|...|:|.||...|:|:.|             ..||.         
  Rat   290 GGLGVVS---DAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEH 351

  Fly   344 -------------PSASSTEDLANSSIL----TGSGSPNSSASAESRGLLESGKVAAMH------ 385
                         |.....|....||||    ...|.|..|......|    .::..||      
  Rat   352 YVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEG----QQLLGMHVVQGPQ 412

  Fly   386 --------NDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHK 419
                    .:|.|.....:|...|..|.  |.||   :|:|:
  Rat   413 VRQLEQQFGEAGSLRGPVLQHQSPKSPQ--QRLL---ELLHR 449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tllNP_524596.1 NR_DBD_TLX 25..117 CDD:143537 40/109 (37%)
NR_LBD 215..436 CDD:416257 54/261 (21%)
ThraNP_112396.2 Modulating 1..52 10/38 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33 5/18 (28%)
NR_DBD_TR 52..138 CDD:143519 35/87 (40%)
NR_LBD_TR 162..370 CDD:132733 40/212 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 457..492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.