DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and Thra

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_112396.2	Gene:	Thra / 81812	RGDID:	3857	Length:	492	Species:	Rattus norvegicus

Alignment Length:	497	Identity:	114/497 - (22%)
Similarity:	169/497 - (34%)	Gaps:	142/497 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QSSEGSPDMMDQKYNSVRLSPAASSRILYHVP--------CKVCRDHSSGKHYGIYACDGCAGFF 58
            ::|..|||...::.|.  ..|..||...| :|        |.||.|.::|.||....|:||.|||
  Rat    16 ENSARSPDGKRKRKNG--QCPLKSSMSGY-IPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFF 77

  Fly    59 KRSIRRSRQ--YVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAV--------QHERGPR 113
            :|:|:::..  |.||  ....||:||..||||:.||.:||..|||..|.|        :.:...:
  Rat    78 RRTIQKNLHPTYSCK--YDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQ 140

  Fly   114 NSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPP 178
            |...||...|.:                                  .|.||.          :|.
  Rat   141 NRERRRKEEMIR----------------------------------SLQQRP----------EPT 161

  Fly   179 PSAAAVLDLSVPRVPHHPVH-QGHH----GFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAE 238
            |....::.::..  .|...: ||.|    ..|.|.....:.:.:........|.|.....:....
  Rat   162 PEEWDLIHVATE--AHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITP 224

  Fly   239 HLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLL---FVYESENANR 300
            .:.:.|::.|.:..|:|||..||::||:....|...|..|....|.:....|   ...:.|....
  Rat   225 AITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKN 289

  Fly   301 EIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISL-------------FRKSP--------- 343
            ..:|:|:   .|..|:...|...|:|.||...|:|:.|             ..||.
  Rat   290 GGLGVVS---DAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEH 351

  Fly   344 -------------PSASSTEDLANSSIL----TGSGSPNSSASAESRGLLESGKVAAMH------ 385
                         |.....|....||||    ...|.|..|......|    .::..||
  Rat   352 YVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEG----QQLLGMHVVQGPQ 412

  Fly   386 --------NDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHK 419
                    .:|.|.....:|...|..|.  |.||   :|:|:
  Rat   413 VRQLEQQFGEAGSLRGPVLQHQSPKSPQ--QRLL---ELLHR 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	40/109 (37%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	54/261 (21%)
Thra	NP_112396.2	Modulating	1..52		10/38 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		5/18 (28%)
		NR_DBD_TR	52..138	CDD:143519	35/87 (40%)
		NR_LBD_TR	162..370	CDD:132733	40/212 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	457..492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910