DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tll and VDR

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001351014.1	Gene:	VDR / 7421	HGNCID:	12679	Length:	494	Species:	Homo sapiens

Alignment Length:	502	Identity:	99/502 - (19%)
Similarity:	177/502 - (35%)	Gaps:	157/502 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSSEGSPDMMDQKYNSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRS 65
            |.:|...||..|...|..|:             |.||.|.::|.|:....|:||.|||:||::|.
Human     4 MAASTSLPDPGDFDRNVPRI-------------CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRK 55

  Fly    66 RQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAV---QHERGPRNSTL-RRHMAMYKD 126
            ..:.|..  .|.|.:.|.:|..|:||||::|.::||.|:.:   :..:..|...| |:.....||
Human    56 ALFTCPF--NGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKD 118

  Fly   127 AMMGAGEMPQIPAE------ILMNTAALTGFPGVPMPMPGLPQRAGHHPAH------MAAFQPP- 178
            ::     .|::..|      ||::                     .||..:      ...|:||
Human   119 SL-----RPKLSEEQQRIIAILLD---------------------AHHKTYDPTYSDFCQFRPPV 157

  Fly   179 ---------PSAAAVLDLSVPRVPHHPVHQG-------HHGFFS----PTAAYMNALATRALPPT 223
                     ||.        |...|.|...|       .|...|    .::::.|...:......
Human   158 RVNDGGGSHPSR--------PNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDD 214

  Fly   224 P-------PLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYL 281
            |       .|....|:.:..:..:.|.:.:.|.:..|.:|...||::||:.|..|..:|...:
Human   215 PSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNE-- 277

  Fly   282 MPMNFAQLLFVYESENANREI-MGMVTREVHAFQEVLNQLC-------HLNIDSTEYECLRAISL 338
               :|......:...|.:.:. :..||:..|:. |::..|.       .||:...|:..|.||.:
Human   278 ---SFTMDDMSWTCGNQDYKYRVSDVTKAGHSL-ELIEPLIKFQVGLKKLNLHEEEHVLLMAICI 338

  Fly   339 FRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQ 403
                                         .|.:..|:.::..:.|:.:...:.|..||:..||..
Human   339 -----------------------------VSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPP 374

  Fly   404 PMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMYSQR 450
            .                     ..|.:.|.|..:..:|.:::.:|::
Human   375 G---------------------SHLLYAKMIQKLADLRSLNEEHSKQ 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	30/94 (32%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	38/235 (16%)
VDR	NP_001351014.1	NR_DBD_VDR	16..122	CDD:143513	36/125 (29%)
		Hinge	97..126		6/33 (18%)
		NR_LBD_VDR	124..426	CDD:132731	57/362 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..190		6/39 (15%)
		Vitamin D3 binding	227..237		1/9 (11%)
		Vitamin D3 binding	271..278		1/11 (9%)
		9aaTAD. /evidence=ECO:0000269\|PubMed:30468856	416..424
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910