Protein Alignment tll and NR1H2

DIOPT Version :9

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_009052.4
• Gene: NR1H2 / 7376
• HGNCID: 7965
• Length: 460
• Species: Homo sapiens
• Alignment Length: 457
• Identity: 109/457 - (23%)
• Similarity: 183/457 - (40%)
• Gaps: 80/457 - (17%)

  Fly     8 PDMMDQKYNSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRR--SRQYVC 70
            ||..::.....:..||  .::|.|..|:||.|.:||.||.:.:|:||.|||:||:.|  :|:|.|
Human    63 PDPEEEPERKRKKGPA--PKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYAC 125

  Fly    71 KSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMP 135
            :.  .|.|.:|...|.:|:.||||||.|.||.:..|..|...|...:|:.       ...:....
Human   126 RG--GGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQ-------QQESQSQS 181

  Fly   136 QIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQG 200
            |.|.....::::.:| ||.   .||..:............|    ..|..:|.:.::....:...
Human   182 QSPVGPQGSSSSASG-PGA---SPGGSEAGSQGSGEGEGVQ----LTAAQELMIQQLVAAQLQCN 238

  Fly   201 HHGFFSPTAAYMNALATRALPPTPPLMAAE------------HIKETAAEHLFKNVNWIKSVRAF 253
            ...|......            ||..:.|:            |..|.|...:.:.|::.|.|..|
Human   239 KRSFSDQPKV------------TPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGF 291

  Fly   254 TELPMPDQLLLLEESWKEFFILAMA-QYLMPMNFAQLL--FVYESENANREIMGMVTREVHAFQE 315
            .:|...||:.||:.|..|..:|..| :|.........|  |.|..::.:|  .|:....::...|
Human   292 LQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHR--AGLQVEFINPIFE 354

  Fly   316 VLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGK 380
            ....:..|.:|..||..|.||::|                             ||:...:.|.|:
Human   355 FSRAMRRLGLDDAEYALLIAINIF-----------------------------SADRPNVQEPGR 390

  Fly   381 VAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISD 445
            |.|:......||.:|.:...|...:||..:|..:..:..:||...|::|..: :.|..:..|:|:
Human   391 VEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALR-LQDKKLPPLLSE 454

  Fly   446 MY 447
            ::
Human   455 IW 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	39/93 (42%)
		NR_LBD	215..436	CDD:416257	51/235 (22%)
NR1H2	NP_009052.4	Transactivation AF-1, required for ligand-independent transactivation function. /evidence=ECO:0000269|PubMed:25661920	1..85		5/23 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..78		2/14 (14%)
		FAP	4..>71	CDD:311241	2/7 (29%)
		NR_DBD_LXR	67..169	CDD:143534	41/105 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..216		8/57 (14%)
		Transactivation AF-2, required for ligand-dependent transactivation function, mediates interaction with CCAR2. /evidence=ECO:0000269|PubMed:25661920	219..460		57/282 (20%)
		NR_LBD_LXR	223..458	CDD:132752	56/278 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910