Protein Alignment tll and NR2C2

DIOPT Version :9

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: XP_011532360.1
• Gene: NR2C2 / 7182
• HGNCID: 7972
• Length: 648
• Species: Homo sapiens
• Alignment Length: 495
• Identity: 127/495 - (25%)
• Similarity: 201/495 - (40%)
• Gaps: 120/495 - (24%)

  Fly    34 CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFE 98
            |.||.|.:||:|||..:|:||.||||||:|::..|.|:|.:.  |:::|.|||:|:.|||:||.|
Human   169 CVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQD--CIINKHHRNRCQFCRLKKCLE 231

  Fly    99 VGMNKDAVQHERGPRN-----------ST--------LR----------------RHMAMYKDAM 128
            :||..::||.||.|.:           ||        ||                |...:....|
Human   232 MGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPGM 296

  Fly   129 MGAGEMPQIPAE--ILMNT--------AALTGFPGVPMPMPGLPQRAGH------HPAHMAAFQ- 176
            :...:.|.|..:  :|:.|        .||.....|...:..|.:...:      .|...:|.:
Human   297 LVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVVTSLANLSESLNNGDTSEIQPEDQSASEI 361

  Fly   177 -----------------PPPSAAAVLDLS-------VPRVPHHPVHQGHHGFFSPTAAYMNALAT 217
                             ..||.|..:|.|       :.|....|:.:......|.|    :....
Human   362 TRAFDTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPIIEVEGPLLSDT----HVTFK 422

  Fly   218 RALP-PTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYL 281
            ..:| |.|..:...:|.|:|:..||.:::|.:|:.||..|.......|:...|.|.|.|.:||..
Human   423 LTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCA 487

  Fly   282 MPMNFAQLL--FVYESENANRE--IMG----MVTREVHAFQEVLNQLCHLNIDSTEYECLRAISL 338
            ..|:.:.:|  .|...:|:.:|  :.|    .|...:...||..|.:..|:||..||..|:||.|
Human   488 QVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVL 552

  Fly   339 FRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQ 403
            |....|                             ||..:.::......|:..|.:|:|:|:...
Human   553 FSPDHP-----------------------------GLTSTSQIEKFQEKAQMELQDYVQKTYSED 588

  Fly   404 PMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLI 443
            ..|...:|..:..:..:||...|||||...||:::|..:|
Human   589 TYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSII 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	43/101 (43%)
		NR_LBD	215..436	CDD:416257	58/229 (25%)
NR2C2	XP_011532360.1	NR_DBD_TR2_like	164..250	CDD:143525	41/82 (50%)
		NR_LBD_TR2_like	413..634	CDD:132750	63/249 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910