DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tll and NR2C1

DIOPT Version :9

Sequence 1:NP_524596.1 Gene:tll / 43656 FlyBaseID:FBgn0003720 Length:452 Species:Drosophila melanogaster
Sequence 2:NP_003288.2 Gene:NR2C1 / 7181 HGNCID:7971 Length:603 Species:Homo sapiens


Alignment Length:550 Identity:131/550 - (23%)
Similarity:198/550 - (36%) Gaps:174/550 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SEGSPDMMDQKYNSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQY 68
            ::.|||....|...:               |.||.|.:||:|||...|:||.||||||||::..|
Human    98 TDNSPDQGPNKVFDL---------------CVVCGDKASGRHYGAVTCEGCKGFFKRSIRKNLVY 147

  Fly    69 VCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRN------------------- 114
            .|:..|.  |:::|.|||:|:.|||::|...||.:|:||.||.|..                   
Human   148 SCRGSKD--CIINKHHRNRCQYCRLQRCIAFGMKQDSVQCERKPIEVSREKSSNCAASTEKIYIR 210

  Fly   115 -----------------------------------------------------------STLRR- 119
                                                                       |||.. 
Human   211 KDLRSPLTATPTFVTDSESTRSTGLLDSGMFMNIHPSGVKTESAVLMTSDKAESCQGDLSTLANV 275

  Fly   120 -----HMAMYKDAMMGAGEMPQIPAEILMN-TAALTGFPGVPMPMPGLPQRA------GHHPAHM 172
                 ::...||....:.||..|  |.|.| ..:|..|.  .|...|...||      ..:|...
Human   276 VTSLANLGKTKDLSQNSNEMSMI--ESLSNDDTSLCEFQ--EMQTNGDVSRAFDTLAKALNPGES 336

  Fly   173 AAFQPPPSAAAVLDLSVPRV----------PHHPVHQGHHGFFSPTAAYMNALATRALP-PTPPL 226
            .|.|   |:.|.::.||..:          ...|:....|..|..|           :| |.|..
Human   337 TACQ---SSVAGMEGSVHLITGDSSINYTEKEGPLLSDSHVAFRLT-----------MPSPMPEY 387

  Fly   227 MAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLLF 291
            :...:|.|:|:..||.:::|..|:.:|..|...:.:.|::..|.|.|.|.:||....||.|.:|.
Human   388 LNVHYIGESASRLLFLSMHWALSIPSFQALGQENSISLVKAYWNELFTLGLAQCWQVMNVATILA 452

  Fly   292 VY--------ESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASS 348
            .:        :.:..:.|...::...:...||..|.:..|.||..||..|:||.||....||..:
Human   453 TFVNCLHNSLQQDKMSTERRKLLMEHIFKLQEFCNSMVKLCIDGYEYAYLKAIVLFSPDHPSLEN 517

  Fly   349 TEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGV 413
            .|                             ::......|.....:||.:|:|....|...||..
Human   518 ME-----------------------------QIEKFQEKAYVEFQDYITKTYPDDTYRLSRLLLR 553

  Fly   414 VQLMHKVSSFTIEELFFRKTIGDITIVRLI 443
            :..:..:::...|||||:..||:|.|..:|
Human   554 LPALRLMNATITEELFFKGLIGNIRIDSVI 583

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tllNP_524596.1 NR_DBD_TLX 25..117 CDD:143537 42/169 (25%)
NR_LBD 215..436 CDD:416257 54/229 (24%)
NR2C1NP_003288.2 Required for interaction with KAT2B. /evidence=ECO:0000250 1..178 37/96 (39%)
NR_DBD_TR2_like 108..194 CDD:143525 42/102 (41%)
NR_LBD_TR2_like 368..589 CDD:132750 60/255 (24%)
Required for interaction with NRIP1. /evidence=ECO:0000250 584..603 130/549 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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