DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and NR2E1

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001273031.1	Gene:	NR2E1 / 7101	HGNCID:	7973	Length:	422	Species:	Homo sapiens

Alignment Length:	440	Identity:	178/440 - (40%)
Similarity:	246/440 - (55%)	Gaps:	64/440 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTH 84
            |..:...||| .:|||||.|.|||||||:||||||:|||||||||:|.|||||..||.|.|||||
Human    40 LLESPGGRIL-DIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTH 103

  Fly    85 RNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALT 149
            |||||||||:||.||.|||||||||||||.||:|:.:|:|   ..|..|          ...|..
Human   104 RNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALY---FRGHKE----------ENGAAA 155

  Fly   150 GFPGVPMPMPGL---PQRAGHHPAHMAAFQPPPSAAAVLDLS--VPRVPHHPVHQGHHGFFSPTA 209
            .||...:|.|..   ..:...|...:||....|....::.|:  .|:.||.         .:.|.
Human   156 HFPSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHE---------VNGTP 211

  Fly   210 AYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFI 274
            .|:..:||            |.:.|:||..||.::.|.|||.||:.|.:.|||:|||::|:|.|:
Human   212 MYLYEVAT------------ESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFV 264

  Fly   275 LAMAQYLMPMNFAQLLFV--YESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAIS 337
            |.:||:.:|::...||.|  ...:|.:.:.:..:..|:.|.|||:.:...|.:|:||:.||:.|.
Human   265 LGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIV 329

  Fly   338 LFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPS 402
            .|:..|               |.|||       |.|....:..:||:.::|:..|::||...:|:
Human   330 TFKAVP---------------THSGS-------ELRSFRNAAAIAALQDEAQLTLNSYIHTRYPT 372

  Fly   403 QPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMYSQRKI 452
            ||.||..||.::..:..:|..||||:||:||||::.|.||:||||....|
Human   373 QPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	72/91 (79%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	75/222 (34%)
NR2E1	NP_001273031.1	NR_DBD_TLX	45..136	CDD:143537	72/91 (79%)
NR2E1	NP_001273031.1	NR_LBD_Tlx_PNR_like	191..406	CDD:132748	81/257 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152593
Domainoid	1	1.000	134	1.000	Domainoid score	I5040
eggNOG	1	0.900	-	-		E33208_3BC6Q
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4525
OMA	1	1.010	-	-		QHG45707
OrthoDB	1	1.010	-	-		D373206at33208
OrthoFinder	1	1.000	-	-		FOG0001683
OrthoInspector	1	1.000	-	-		oto88337
orthoMCL	1	0.900	-	-		OOG6_108295
Panther	1	1.100	-	-	LDO	PTHR24083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10591
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.700