Protein Alignment tll and THRB

DIOPT Version :9

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_000452.2
• Gene: THRB / 7068
• HGNCID: 11799
• Length: 461
• Species: Homo sapiens
• Alignment Length: 388
• Identity: 97/388 - (25%)
• Similarity: 141/388 - (36%)
• Gaps: 117/388 - (30%)

  Fly     9 DMMDQKYNSVRLSPAASSRILYHVP--------CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRS 65
            |:.||..:|.:.......:...::|        |.||.|.::|.||....|:||.|||:|:|:::
Human    74 DVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKN 138

  Fly    66 --RQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAV--------QHERGPRNSTLRRH 120
              ..|.||  .:|.||:||..||||:.||.:||..|||..|.|        :.:....|...||.
Human   139 LHPSYSCK--YEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRR 201

  Fly   121 MAMYKDAMMGAGEMPQIPAE--ILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAA 183
            ..:.|    ..|..|:...|  .|:.|..                     .||:|...
Human   202 EELQK----SIGHKPEPTDEEWELIKTVT---------------------EAHVATNA------- 234

  Fly   184 VLDLSVPRVPHHPVHQGHH----GFFSP----TAAYMNALATRALPPTP-----PLMAAEHIKET 235
                           ||.|    ..|.|    .|..:||         |     .|.|..|..:.
Human   235 ---------------QGSHWKQKRKFLPEDIGQAPIVNA---------PEGGKVDLEAFSHFTKI 275

  Fly   236 AAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLLFVYESE--NA 298
            ....:.:.|::.|.:..|.|||..||::||:....|...|..|....|          |||  ..
Human   276 ITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDP----------ESETLTL 330

  Fly   299 NREI-----------MGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTE 350
            |.|:           :|:|:   .|..::...|...|:|.||...|:|:.|.....|..:..|
Human   331 NGEMAVTRGQLKNGGLGVVS---DAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVE 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	38/109 (35%)
		NR_LBD	215..436	CDD:416257	36/154 (23%)
THRB	NP_000452.2	Modulating	1..106		5/31 (16%)
		NR_DBD_TR	106..192	CDD:143519	36/87 (41%)
		NR_LBD_TR	216..458	CDD:132733	50/240 (21%)
		Interaction with NR2F6. /evidence=ECO:0000269|PubMed:10713182	244..461		41/169 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910