DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and THRA

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001177848.1	Gene:	THRA / 7067	HGNCID:	11796	Length:	490	Species:	Homo sapiens

Alignment Length:	500	Identity:	112/500 - (22%)
Similarity:	171/500 - (34%)	Gaps:	148/500 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QSSEGSPDMMDQKYN---SVRLSPAASSRILYHVP--------CKVCRDHSSGKHYGIYACDGCA 55
            ::|..|||...::.|   |::.|.:.      ::|        |.||.|.::|.||....|:||.
Human    16 ENSARSPDGKRKRKNGQCSLKTSMSG------YIPSYLDKDEQCVVCGDKATGYHYRCITCEGCK 74

  Fly    56 GFFKRSIRRSRQ--YVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAV--------QHER 110
            |||:|:|:::..  |.||  ....||:||..||||:.||.:||..|||..|.|        :.:.
Human    75 GFFRRTIQKNLHPTYSCK--YDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKL 137

  Fly   111 GPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAF 175
            ..:|...||...|.:                                  .|.||.
Human   138 IEQNRERRRKEEMIR----------------------------------SLQQRP---------- 158

  Fly   176 QPPPSAAAVLDLSVPRVPHHPVH-QGHH----GFFSPTAAYMNALATRALPPTPPLMAAEHIKET 235
            :|.|....::.::..  .|...: ||.|    ..|.|.....:.:.:........|.|.....:.
Human   159 EPTPEEWDLIHIATE--AHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKI 221

  Fly   236 AAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLL---FVYESEN 297
            ....:.:.|::.|.:..|:|||..||::||:....|...|..|....|.:....|   ...:.|.
Human   222 ITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQ 286

  Fly   298 ANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISL-------------FRKSP------ 343
            .....:|:|:   .|..|:...|...|:|.||...|:|:.|             ..||.
Human   287 LKNGGLGVVS---DAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLA 348

  Fly   344 ----------------PSASSTEDLANSSIL----TGSGSPNSSASAESRGLLESGKVAAMH--- 385
                            |.....|....||||    ...|.|..|......|    .::..||
Human   349 FEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEG----QQLLGMHVVQ 409

  Fly   386 -----------NDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHK 419
                       .:|.|.....:|...|..|.  |.||   :|:|:
Human   410 GPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQ--QRLL---ELLHR 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	37/109 (34%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	54/260 (21%)
THRA	NP_001177848.1	Modulating	1..52		8/41 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		5/15 (33%)
		NR_DBD_TR	52..138	CDD:143519	35/87 (40%)
		NR_LBD_TR	162..370	CDD:132733	40/212 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	457..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910