DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and RXRB

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001257330.1	Gene:	RXRB / 6257	HGNCID:	10478	Length:	537	Species:	Homo sapiens

Alignment Length:	438	Identity:	114/438 - (26%)
Similarity:	176/438 - (40%)	Gaps:	119/438 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRN 86
            |.|..|:     |.:|.|.|||||||:|:|:||.|||||:||:...|.|:..|.  |.|||..||
Human   198 PGAGKRL-----CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKD--CTVDKRQRN 255

  Fly    87 QCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDA-MMGAGEMPQ-------IPAEILM 143
            :|:.||.:||...||.::|||.|         |.....||. ..|||..|:       :.||:.:
Human   256 RCQYCRYQKCLATGMKREAVQEE---------RQRGKDKDGDGEGAGGAPEEMPVDRILEAELAV 311

  Fly   144 NTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPT 208
            ...:..|..|     ||....:|..                        |:.||
Human   312 EQKSDQGVEG-----PGGTGGSGSS------------------------PNDPV----------- 336

  Fly   209 AAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFF 273
                                 .:|.:.|.:.||..|.|.|.:..|:.||:.||::||...|.|..
Human   337 ---------------------TNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELL 380

  Fly   274 ILAMAQYLMPMN----FAQLLFVYESENANREIMGMVTREV-HAFQEVLNQLCHLNIDSTEYECL 333
            |.:.:...:.:.    .|..|.|:.:...:..:..:..|.: ....|:::::..:.:|.||..||
Human   381 IASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRSLSRVLTELVSKMRDMRMDKTELGCL 445

  Fly   334 RAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQR 398
            |||.||                             :.:::||....:|..:.....::|..|.::
Human   446 RAIILF-----------------------------NPDAKGLSNPSEVEVLREKVYASLETYCKQ 481

  Fly   399 THPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDM 446
            .:|.|..||..||..:..:..:....:|.|||.|.|||..|...:.:|
Human   482 KYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEM 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	42/91 (46%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	49/225 (22%)
RXRB	NP_001257330.1	Modulating. /evidence=ECO:0000250	1..204		2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..181
		NR_DBD_RXR	204..279	CDD:143514	41/90 (46%)
		Hinge	271..295		10/32 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..299		9/31 (29%)
		NR_LBD_RXR_like	298..515	CDD:132741	57/306 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..336		6/51 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910