DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tll and RXRA

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_002948.1	Gene:	RXRA / 6256	HGNCID:	10477	Length:	462	Species:	Homo sapiens

Alignment Length:	467	Identity:	122/467 - (26%)
Similarity:	189/467 - (40%)	Gaps:	124/467 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SEGSPDM---MDQKYNSVRLSPAASSRILYHVP--------------CKVCRDHSSGKHYGIYAC 51
            |.|||.:   |:...:|..:.|......:..||              |.:|.|.|||||||:|:|
Human    88 STGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSC 152

  Fly    52 DGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHER---GPR 113
            :||.|||||::|:...|.|:..|.  |::||..||:|:.||.:||..:||.::|||.||   ..|
Human   153 EGCKGFFKRTVRKDLTYTCRDNKD--CLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDR 215

  Fly   114 NSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPP 178
            |.                            |....|......||:
Human   216 NE----------------------------NEVESTSSANEDMPV-------------------- 232

  Fly   179 PSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKN 243
               ..:|:..:...|             .|..|:.  |...|.|:.|.....:|.:.|.:.||..
Human   233 ---ERILEAELAVEP-------------KTETYVE--ANMGLNPSSPNDPVTNICQAADKQLFTL 279

  Fly   244 VNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMN----FAQLLFVYESENANREIMG 304
            |.|.|.:..|:|||:.||::||...|.|..|.:.:...:.:.    .|..|.|:.: :|:...:|
Human   280 VEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRN-SAHSAGVG 343

  Fly   305 MVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSAS 369
            .:...|  ..|:::::..:.:|.||..|||||.||                             :
Human   344 AIFDRV--LTELVSKMRDMQMDKTELGCLRAIVLF-----------------------------N 377

  Fly   370 AESRGLLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTI 434
            .:|:||....:|.|:.....::|..|.:..:|.||.||..||..:..:..:....:|.|||.|.|
Human   378 PDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLI 442

  Fly   435 GDITIVRLISDM 446
            ||..|...:.:|
Human   443 GDTPIDTFLMEM 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	44/108 (41%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	59/224 (26%)
RXRA	NP_002948.1	Modulating. /evidence=ECO:0000250	1..134		9/45 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..107		6/18 (33%)
		Nuc_recep-AF1	17..126	CDD:403126	9/37 (24%)
		NR_DBD_RXR	133..209	CDD:143514	38/77 (49%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:12145331	160..165		2/4 (50%)
		Hinge	201..224		8/50 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..228		7/49 (14%)
		NR_LBD_RXR_like	229..440	CDD:132741	63/280 (23%)
		Required for nuclear export. /evidence=ECO:0000269\|PubMed:15509776	348..368		5/21 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910