DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tll and RORB

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001351952.1	Gene:	RORB / 6096	HGNCID:	10259	Length:	470	Species:	Homo sapiens

Alignment Length:	486	Identity:	113/486 - (23%)
Similarity:	202/486 - (41%)	Gaps:	138/486 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 NSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVV 80
            |.::....|:::|.. :|||:|.|.|||.|||:..|:||.|||:||.:.:..|.|..|:.  |::
Human     4 NQLKTKADATAQIEV-IPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRN--CLI 65

  Fly    81 DKTHRNQCRACRLRKCFEVGMNKDAV------QHERGPRNSTLRRH-MAMYKDAMMGAGEMPQIP 138
            |:|:||:|:.|||:||..:||::|||      :.:|....:.:::| ..:.:.....:||
Human    66 DRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGE----- 125

  Fly   139 AEIL---MNTAALTGFPGVPMPMPG---------LPQRAGHHPAHMAAFQPPPSAAAVLDLSVPR 191
            ||.|   .:::...|...:.....|         ||:..|::  ::.:.||.|..:.:....:.:
Human   126 AEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYY--NVDSGQPSPDQSGLDMTGIKQ 188

  Fly   192 VPHHPVH------------QGHHGFFSP--------------------TAAY----MNALATRAL 220
            :...|::            ..::|..:|                    |..|    ::.||.:.
Human   189 IKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQT- 252

  Fly   221 PPTPPLMAAEHIK---ETAAEHLFKN------------VNWIKSVRAFTELPMPDQLLLLEESWK 270
                  ...|.||   ..:.|.|::.            |.:.|.:..|.||...||:|||:....
Human   253 ------HTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCL 311

  Fly   271 EFFILAMAQYLMPMNFAQLLFVYESENANREIMGMVTREVHAFQEVLNQ-------LCHLNIDST 328
            |..::.|.:...|:|...|   :|.:..     ||...:.....:::|:       ||.|.:  |
Human   312 EVVLVRMCRAFNPLNNTVL---FEGKYG-----GMQMFKALGSDDLVNEAFDFAKNLCSLQL--T 366

  Fly   329 EYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALH 393
            |.|    |:||              :|::|         .|.:...|:|..||..:......||.
Human   367 EEE----IALF--------------SSAVL---------ISPDRAWLIEPRKVQKLQEKIYFALQ 404

  Fly   394 NYIQRTHPSQPMRFQTLLGVVQLMHKVSSFT 424
            :.||:.|    :..:||   .:|:.|:.:.|
Human   405 HVIQKNH----LDDETL---AKLIAKIPTIT 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	40/97 (41%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	52/232 (22%)
RORB	NP_001351952.1	NR_DBD_ROR	14..108	CDD:143526	40/96 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..127		3/27 (11%)
		NR_LBD_ROR_like	221..461	CDD:132737	54/259 (21%)
		AF-2	456..461
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910