DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and Nr1h4

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	XP_008763482.1	Gene:	Nr1h4 / 60351	RGDID:	628831	Length:	516	Species:	Rattus norvegicus

Alignment Length:	415	Identity:	91/415 - (21%)
Similarity:	149/415 - (35%)	Gaps:	108/415 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKT 83
            |::.:::.||.....|.||.|.:||.||....|:||.|||:|||.::..|.||:  .|.||:|..
  Rat   152 RMAASSAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKN--GGNCVMDMY 214

  Fly    84 HRNQCRACRLRKCFEVGMNKDAVQ----HERGPRNSTLRRHMAMYKDAMMG----AGEMPQIPA- 139
            .|.:|:.||||||.|:||..:.:.    .|...::..||:::..:.|..:.    ..::.|:.:
  Rat   215 MRRKCQDCRLRKCREMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTST 279

  Fly   140 --------EILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLD-LSVPRVPHH 195
                    |:.::...|..:                                ::| .|..|:|..
  Rat   280 TKLCREKTELTVDQQTLLDY--------------------------------IMDSYSKQRMPQE 312

  Fly   196 PVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPD 260
            ..::.....||   |..|.|.               :.|.|..|:...|.:.|.:..|..|...|
  Rat   313 ITNKILKEEFS---AEENFLI---------------LTEMATSHVQILVEFTKRLPGFQTLDHED 359

  Fly   261 QLLLLEESWKEFFILAMAQYL---MPMNFAQLLFVYESENANREIMGMVTREVHAFQEVLNQLCH 322
            |:.||:.|..|...|..|:..   :|...|.||   |.......|.......:.:|.:.:.:
  Rat   360 QIALLKGSAVEAMFLRSAEIFNKKLPAGHADLL---EERIRKSGISDEYITPMFSFYKSVGE--- 418

  Fly   323 LNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHND 387
            |.:...||..|.||.:.                             |.:.:.:.:...|..:...
  Rat   419 LKMTQEEYALLTAIVIL-----------------------------SPDRQYIKDREAVEKLQEP 454

  Fly   388 ARSALHNYIQRTHPSQPMRFQTLLG 412
            ....|....:...|..|..|..|||
  Rat   455 LLDVLQKLCKIYQPENPQHFACLLG 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	38/95 (40%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	38/201 (19%)
Nr1h4	XP_008763482.1	NR_DBD_FXR	164..251	CDD:143520	36/88 (41%)
Nr1h4	XP_008763482.1	NR_LBD_Fxr	292..511	CDD:132734	47/273 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910