DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tll and Nr5a2

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_068510.1	Gene:	Nr5a2 / 60349	RGDID:	68353	Length:	560	Species:	Rattus norvegicus

Alignment Length:	502	Identity:	117/502 - (23%)
Similarity:	203/502 - (40%)	Gaps:	133/502 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFE 98
            |.||.|..||.|||:..|:.|.|||||:::..::|.|...:.  |.:|||.|.:|..||.:||.:
  Rat   107 CPVCGDKVSGYHYGLLTCESCKGFFKRTVQNQKRYTCIENQN--CQIDKTQRKRCPYCRFKKCID 169

  Fly    99 VGMNKDAVQHE--RGPRNS---TLRRHMAM--YKDAMMGAG-----EMPQI----PAEILMNTAA 147
            |||..:||:.:  ||.||.   ..:|..|:  .|.|::.|.     .|.|:    |:::   |:|
  Rat   170 VGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDL---TSA 231

  Fly   148 L----TGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGH--HGFF- 205
            :    :...|:|:....||.         ..:...|...:.:.:::|  ||..:| |:  :|.|
  Rat   232 IQNIHSASKGLPLSHVALPP---------TDYDRSPFVTSPISMTMP--PHGSLH-GYQPYGHFP 284

  Fly   206 --------------SPTA----AYMNALATRALPPTPPLMAAEHIK------------------- 233
                          ||.:    :||:...|.: |.:.|.:..|.:|
  Rat   285 NRAIKSEYPDPYSSSPESMMGYSYMDGYQTSS-PASIPHLILELLKCEPDEPQVQAKIMAYLQQE 348

  Fly   234 -----------------ETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYL 281
                             :.|.:.||..|.|.:|...|.||.:.||:.||:..|.|..||......
  Rat   349 QNNRNRQEKLSAFGLLCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQ 413

  Fly   282 MPMNFAQLLFVYESENANREIMGMVTREVHAF-------QEVLNQLCHLNIDSTEYECLRAISLF 339
            :.......:|:...|:.  :...:::....||       ||::.:|..|..|..|:.||:.:.||
  Rat   414 VAHGKEGTIFLVTGEHV--DYSSIISNTEVAFNNLLSLAQELVVRLRSLQFDQREFVCLKFLVLF 476

  Fly   340 RKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQP 404
                  :|..::|.|..::.|                       :.....:||.:|....:|.|.
  Rat   477 ------SSDVKNLENFQLVEG-----------------------VQEQVNAALLDYTLCNYPQQT 512

  Fly   405 MRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMYSQRK 451
            .:|..||..:..:..:|....:.|:::...||:....|:.:|...::
  Rat   513 EKFGQLLLRLPEIRAISKQAEDYLYYKHVNGDVPYNNLLIEMLHAKR 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	37/87 (43%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	50/263 (19%)
Nr5a2	NP_068510.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..54
		NR_DBD_Lrh-1_like	107..199	CDD:143541	38/93 (41%)
		FTZ-F1 box. /evidence=ECO:0000250	176..205		9/28 (32%)
		NR_LBD_Lrh-1	320..560	CDD:132754	52/271 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910