DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and RARB

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001277145.1	Gene:	RARB / 5915	HGNCID:	9865	Length:	455	Species:	Homo sapiens

Alignment Length:	448	Identity:	111/448 - (24%)
Similarity:	173/448 - (38%)	Gaps:	121/448 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SEGSPDMMD-QKYNSVRLSPAASSRI---LYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRR 64
            |..||..:: |..:|..|.|:..|.:   ..:.||.||:|.|||.|||:.||:||.|||:|||::
Human    54 STPSPATIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQK 118

  Fly    65 SRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAMM 129
            :..|.|...|.  ||::|..||:|:.|||:|||||||:|::|:::|..:.....:........|
Human   119 NMIYTCHRDKN--CVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEM- 180

  Fly   130 GAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPH 194
             ..|:..:..:|                          ..||...|
Human   181 -TAELDDLTEKI--------------------------RKAHQETF------------------- 199

  Fly   195 HPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEH-----------IKETAAEHLFKNVNWIK 248
                        |:...:....|.:        :|:|           ..|.|.:.:.|.|.:.|
Human   200 ------------PSLCQLGKYTTNS--------SADHRVRLDLGLWDKFSELATKCIIKIVEFAK 244

  Fly   249 SVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMP----MNFAQLLFVYESENANREIMGMVTRE 309
            .:..||.|.:.||:.||:.:..:..||.:.....|    |.|:..|.:..::..|.. .|.:|..
Human   245 RLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAG-FGPLTDL 308

  Fly   310 VHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRG 374
            |..|   .|||..|.:|.||...|.||.|.                             ..:.:.
Human   309 VFTF---ANQLLPLEMDDTETGLLSAICLI-----------------------------CGDRQD 341

  Fly   375 LLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRK 432
            |.|..||..:......||..||::..||:|..|..:|..:..:..:|:...|.:...|
Human   342 LEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLK 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	44/94 (47%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	53/233 (23%)
RARB	NP_001277145.1	Modulating	1..87		8/32 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..78		7/23 (30%)
		NR_DBD_RAR	82..166	CDD:143522	43/85 (51%)
		Hinge	154..182		4/29 (14%)
		NR_LBD_RAR	186..416	CDD:132735	58/312 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..455
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910