Protein Alignment tll and RARA

DIOPT Version :9

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: XP_005257609.1
• Gene: RARA / 5914
• HGNCID: 9864
• Length: 478
• Species: Homo sapiens
• Alignment Length: 427
• Identity: 102/427 - (23%)
• Similarity: 166/427 - (38%)
• Gaps: 119/427 - (27%)

  Fly    21 SPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHR 85
            ||....||  :.||.||:|.|||.|||:.||:||.|||:|||:::..|.|...|.  |:::|..|
Human    93 SPPPLPRI--YKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKN--CIINKVTR 153

  Fly    86 NQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTG 150
            |:|:.|||:|||||||:|::|:::|..:..                 |:|:
Human   154 NRCQYCRLQKCFEVGMSKESVRNDRNKKKK-----------------EVPK-------------- 187

  Fly   151 FPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNAL 215
                              |....::...|....:::         .|.:.|...| |....:...
Human   188 ------------------PECSESYTLTPEVGELIE---------KVRKAHQETF-PALCQLGKY 224

  Fly   216 ATRALPPTPPLMAAEH-----------IKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESW 269
            .|.        .::|.           ..|.:.:.:.|.|.:.|.:..||.|.:.||:.||:.:.
Human   225 TTN--------NSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAAC 281

  Fly   270 KEFFILAMAQYLMP----MNFAQLLFVYESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTEY 330
            .:..||.:.....|    |.|:..|.:..::..|.. .|.:|..|.||   .|||..|.:|..|.
Human   282 LDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAG-FGPLTDLVFAF---ANQLLPLEMDDAET 342

  Fly   331 ECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNY 395
            ..|.||.|.                             ..:.:.|.:..:|..:......||..|
Human   343 GLLSAICLI-----------------------------CGDRQDLEQPDRVDMLQEPLLEALKVY 378

  Fly   396 IQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRK 432
            :::..||:|..|..:|..:..:..:|:...|.:...|
Human   379 VRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLK 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	44/91 (48%)
		NR_LBD	215..436	CDD:416257	48/233 (21%)
RARA	XP_005257609.1	NR_DBD_RAR	98..182	CDD:143522	44/87 (51%)
		NR_LBD_RAR	202..432	CDD:132735	52/265 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910