DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and Nr1h3

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_113815.2	Gene:	Nr1h3 / 58852	RGDID:	61909	Length:	445	Species:	Rattus norvegicus

Alignment Length:	455	Identity:	106/455 - (23%)
Similarity:	183/455 - (40%)	Gaps:	92/455 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SEGSPDMMDQKYNSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQY 68
            :|..|:..:.:....:..||  .::|.:..|.||.|.:||.||.:.:|:||.|||:||:.:..:|
  Rat    68 AETLPEPTELRPQKRKKGPA--PKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGARY 130

  Fly    69 VCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGE 133
            :|.|  .|.|.:|...|.:|:.||||||.:.||.::.|..|...|...|:|.            |
  Rat   131 ICHS--GGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQ------------E 181

  Fly   134 MPQIPAEILMNTAALTGFPGVPMPMPGL-PQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPV 197
            ..|..|     |:........|..:|.| |::.|.....:||.|
  Rat   182 EEQAQA-----TSVSPRVSSPPQVLPQLSPEQLGMIEKLVAAQQ--------------------- 220

  Fly   198 HQGHHGFFSPTAAYMNALATRALPPTPPLMAAE-------HIKETAAEHLFKNVNWIKSVRAFTE 255
             |.:...||      :.|.....|..|...:.|       |..|.|...:.:.|::.|.:..|.:
  Rat   221 -QCNRRSFS------DRLRVTPWPIAPDPQSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQ 278

  Fly   256 LPMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLLFVYESENANREIM---GMVTREVHAFQEVL 317
            |...||:.||:.|..|..:|..::...|  .::.:...:..:.|||..   |:....::...|..
  Rat   279 LSREDQIALLKTSAIEVMLLETSRRYNP--GSESITFLKDFSYNREDFAKAGLQVEFINPIFEFS 341

  Fly   318 NQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVA 382
            ..:..|.::..|:..|.|||:|                             ||:...:.:..:|.
  Rat   342 RSMNELQLNDAEFALLIAISIF-----------------------------SADRPNVQDQLQVE 377

  Fly   383 AMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMY 447
            .:.:....|||.|:...||...:.|..:|..:..:..:||...|::|..: :.|..:..|:|:::
  Rat   378 RLQHTYVEALHAYVSINHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALR-LQDKKLPPLLSEIW 441

Fly 448 447
Rat 442 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	36/91 (40%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	46/230 (20%)
Nr1h3	NP_113815.2	Transactivation AF-1, required for ligand-independent transactivation function. /evidence=ECO:0000250\|UniProtKB:Q13133	1..94		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..86		2/17 (12%)
		NR_DBD_LXR	76..176	CDD:143534	38/103 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..200		6/38 (16%)
		Transactivation AF-2, required for ligand-dependent transactivation function, mediates interaction with CCAR2. /evidence=ECO:0000250\|UniProtKB:Q13133	203..445		58/299 (19%)
		NR_LBD_LXR	208..443	CDD:132752	56/294 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910