DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and pgr

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001159807.1	Gene:	pgr / 569575	ZFINID:	ZDB-GENE-990415-214	Length:	617	Species:	Danio rerio

Alignment Length:	397	Identity:	93/397 - (23%)
Similarity:	150/397 - (37%)	Gaps:	90/397 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFE 98
            |.:|.|.:||.|||:..|..|..|||.::.....|:|..:..  |:|||..|..|.|||||||::
Zfish   251 CVICGDEASGCHYGVLTCGSCKVFFKTAVEGHHNYLCAGRND--CIVDKIRRKNCPACRLRKCYQ 313

  Fly    99 VGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQ 163
            .||.....:.:|          .|..|...:....|.|.|..:|.:...|:..|.:
Zfish   314 AGMMLGGRKMKR----------FAGLKVMGLSPSLMFQSPLSLLTDGQTLSSLPCM--------- 359

  Fly   164 RAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMA 228
                  :.|...|..|...::|:...|:|    |:.|          |.|.      .|..|.:.
Zfish   360 ------SAMRELQLSPQMISILENIEPQV----VYSG----------YDNT------QPEVPHLL 398

  Fly   229 AEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMA----QYLMP--MNFA 287
            ...:.......|...|.|.||:..|..|.:.||:.|::.||....:.::.    |.:.|  :.||
Zfish   399 LNSLNRLCERQLLWIVRWSKSLPGFRNLHINDQMTLIQYSWMGLMLFSLGWRTFQNVTPDYLYFA 463

  Fly   288 QLLFVYESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSP----PSASS 348
            ..|.:...:.....|..:..    |.|.|..:..:|.:...|:.|::|:.|....|    .|.:.
Zfish   464 PDLVLSNDQLRRSPIYDLCL----AMQFVPQEFANLQVTKEEFLCMKALMLLNTVPLEGLKSQTQ 524

  Fly   349 TEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGV 413
            .:::..:.|...|         ::..|.|.|.||:                  ||  ||..|..:
Zfish   525 FDEMRQNYICELS---------KAIQLKEKGVVAS------------------SQ--RFYHLTKL 560

  Fly   414 VQLMHKV 420
            :..||::
Zfish   561 MDNMHEI 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	31/82 (38%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	44/216 (20%)
pgr	NP_001159807.1	Na_K-ATPase	<71..>125	CDD:298651
		zinc finger DBD	246..316		28/66 (42%)
		NR_DBD_GR_PR	247..324	CDD:143546	30/74 (41%)
		NR_LBD_PR	370..617	CDD:132759	51/251 (20%)
		LBD	404..567		42/195 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910