DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tll and rorb

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001076325.1	Gene:	rorb / 567943	ZFINID:	ZDB-GENE-061204-2	Length:	466	Species:	Danio rerio

Alignment Length:	507	Identity:	110/507 - (21%)
Similarity:	193/507 - (38%)	Gaps:	149/507 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 VPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKC 96
            :|||:|.|.|||.|||:..|:||.|||:||.:.:..|.|..|:.  |::|:|:||:|:.|||:||
Zfish     8 IPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRN--CLIDRTNRNRCQHCRLQKC 70

  Fly    97 FEVGMNKDAV------QHERGPRNSTLRRH-MAMYKDAMMGAGE---MPQIPAEILMNTAAL--- 148
            ..:||::|||      :.:|....:.:::| ..:.:......||   :.::.:..|.|..:.
Zfish    71 LALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQTGEAEALARVYSSSLTNGLSTLNH 135

  Fly   149 ----TGFPGVPMPMP-----GLPQRAGHHPAHMAAFQPPPSAAAVLDLS-VPRVPHHPVHQGHHG 203
                |...|..:.||     |.|  .|::........|..|.   ||:: :.::...|::.
Zfish   136 EIGGTYANGHVIDMPKGQANGAP--GGYYGMDSTQASPDQSG---LDITGMKQIKQEPIYD---- 191

  Fly   204 FFSPTAAYMNALATRALPPTPPLM------------------------------------AAEHI 232
                            |.|.|.|.                                    .||.:
Zfish   192 ----------------LTPVPNLFTYGSYQDSQLAPGVSMGELDRIAQNIIKSHLETCQYTAEEL 240

  Fly   233 KETAAE-HLFKNVN----------W-----------------IKSVRAFTELPMPDQLLLLEESW 269
            ::.|.: |.::.|.          |                 .|.:..|.||...||:|||:...
Zfish   241 QQLAWQTHSYEEVKMYQSKTRDVLWQQCAIQVTHAIQYVVEFAKRITGFMELCQNDQILLLKSGC 305

  Fly   270 KEFFILAMAQYLMPMNFAQLLFVYESENANREIMGMVTRE--VHAFQEVLNQLCHLNIDSTEYEC 332
            .|..::.|.:...|:|...|   :|.:....:|...:..:  |.|..:....||.|.:  ||.|
Zfish   306 LEVVLVRMCRAFNPLNNTVL---FEGKYGGMQIFKTLGCDDLVSAVFDFAKSLCSLQL--TEEE- 364

  Fly   333 LRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQ 397
               |:||              ::::|..:..|         .|:|..||..:......||.:.:|
Zfish   365 ---IALF--------------SAAVLISTDRP---------WLMEPRKVQKLQEKIYFALQHIMQ 403

  Fly   398 RTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMYSQ 449
            :.|..:. ....|:..:..:..:.:...|||...:.:...|:..|...:|.:
Zfish   404 KNHLDED-ALAKLISRIPTLSALCTLHTEELQAFQQLHPETVNMLFPPLYKE 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	39/90 (43%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	51/286 (18%)
rorb	NP_001076325.1	NR_DBD_ROR	3..97	CDD:143526	39/90 (43%)
rorb	NP_001076325.1	NR_LBD_ROR_like	217..456	CDD:132737	50/271 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910