DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tll and vdrb

DIOPT Version :9

Sequence 1:NP_524596.1 Gene:tll / 43656 FlyBaseID:FBgn0003720 Length:452 Species:Drosophila melanogaster
Sequence 2:NP_001153457.1 Gene:vdrb / 564511 ZFINID:ZDB-GENE-080403-10 Length:422 Species:Danio rerio


Alignment Length:502 Identity:105/502 - (20%)
Similarity:175/502 - (34%) Gaps:163/502 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MQSSEGSPDMMDQKYNSVRLSPAASSRILYHVP--CKVCRDHSSGKHYGIYACDGCAGFFKRSIR 63
            :.:|...||..|:                 :||  |.||.|.::|.|:....|:||.|||:||::
Zfish     5 VSTSTQVPDEFDR-----------------NVPRICGVCGDKATGFHFNAMTCEGCKGFFRRSMK 52

  Fly    64 RSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAV-QHERGPRNSTL---RRHMAMY 124
            |...:.|..  .|.|.:.|.:|..|:||||::|.::||.|:.: ..|...|...|   |:....:
Zfish    53 RKASFTCPF--NGSCTITKDNRRHCQACRLKRCLDIGMMKEFILTDEEVQRKKELIQRRKDEEAH 115

  Fly   125 KDAMMGAGEMPQIPAE--ILMNTAALTGFPGVPMPMPGLPQRAGHHPAH------MAAFQPP--- 178
            ::|     :.|::..|  .:::|..                 ..||..:      .:.|:||   
Zfish   116 REA-----QKPRLSDEQRNIIDTLV-----------------DAHHKTYDDSYSDFSRFRPPVRE 158

  Fly   179 ------PSAAAVL----DLSVPRVPHHP--------------VHQGHHGFFSPTAAYMNALATRA 219
                  .|.||.|    |.|.....|.|              ::|......||.:...:..:...
Zfish   159 GPVTRSASRAASLHSLSDASSDSFSHSPESGDRKMNLSNLLMMYQEQGLSSSPDSKEEDGSSLSM 223

  Fly   220 LPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYL--- 281
            ||         |:.:..:..:.|.:.:.|.:..|.||...||:.||:.|..|..:|...|..   
Zfish   224 LP---------HLADLVSYSIQKVIGFAKMIPGFRELTAEDQIALLKSSAIEVIMLRSNQSFSLE 279

  Fly   282 -MPMNFAQLLFVYESENANREIMGMVTREVHAFQEVLNQLC-------HLNIDSTEYECLRAISL 338
             |..:.....|.|        .:..||:..|.. |:|..|.       .||:...|:..|.||.|
Zfish   280 DMSWSCGGPEFKY--------CVNDVTKAGHTL-ELLEPLVKFQVGLKKLNLHEEEHVLLMAICL 335

  Fly   339 FRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQ 403
            .....|                             |:.:..:|.|:.:.....|..||:..||. 
Zfish   336 LSPDRP-----------------------------GVQDHVRVEALQDKVSEVLQAYIRAHHPG- 370

  Fly   404 PMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMYSQR 450
                                  ..|.:.|.|..:..:|.:::.:|::
Zfish   371 ----------------------GRLLYAKMIQKLADLRSLNEEHSKQ 395

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tllNP_524596.1 NR_DBD_TLX 25..117 CDD:143537 33/94 (35%)
NR_LBD 215..436 CDD:416257 44/231 (19%)
vdrbNP_001153457.1 NR_DBD_VDR 15..121 CDD:143513 37/129 (29%)
Hinge 96..125 6/33 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 106..128 4/26 (15%)
NR_LBD 123..421 CDD:299703 64/360 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 145..190 11/44 (25%)
Vitamin D3 binding. /evidence=ECO:0000250 224..234 3/18 (17%)
Interaction with coactivator LXXLL motif. /evidence=ECO:0000250 243..261 7/17 (41%)
Vitamin D3 binding. /evidence=ECO:0000250 268..275 1/6 (17%)
9aaTAD. /evidence=ECO:0000250|UniProtKB:P11473 411..419
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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