DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and pparaa

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001154805.1	Gene:	pparaa / 563298	ZFINID:	ZDB-GENE-041210-169	Length:	470	Species:	Danio rerio

Alignment Length:	548	Identity:	108/548 - (19%)
Similarity:	176/548 - (32%)	Gaps:	222/548 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SPDMMDQKYNSVR-------------------LSPAA--SSRIL-------------YHVPCKVC 37
            |..:.|..:||..                   |:||:  ||.:.             ..:.|:||
Zfish    38 SQSLSDDTFNSFHMLDYQNCDTAVDNSSILDVLTPASSPSSEVFSASTGQDENSSGSLTLECRVC 102

  Fly    38 RDHSSGKHYGIYACDGCAGFFKRSIRRSRQY-VCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGM 101
            .|.:||.|||::||:||.|||:|:||...:| .|:..    |.:.|.:||:|:.||.|||..|||
Zfish   103 ADRASGFHYGVHACEGCKGFFRRTIRLKLEYDKCERN----CKIQKKNRNKCQYCRFRKCLAVGM 163

  Fly   102 NKDAVQHERGPRNSTLR-----------RHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVP 155
            :.:|::..|.|::...|           .|.....|....|.:|
Zfish   164 SHNAIRFGRIPQSEKQRLKAEQDVSGKEEHKCQQPDMRSLARQM--------------------- 207

  Fly   156 MPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRAL 220
                        |.|::..|....:.|.|........|...:|.            |:.|
Zfish   208 ------------HEAYLKHFHMNKAKARVFLTGKTSTPPFVIHD------------MDTL----- 243

  Fly   221 PPTPPLMAAEHIKETAAEHLFKNV---------------------------------NWIKSVRA 252
                     :|.::.....|..||                                 .:.|:|..
Zfish   244 ---------QHAEKKLVTQLLGNVASGDISTLQEREVEARLFLFCQYASVATVTELTEYAKAVPG 299

  Fly   253 FTELPMPDQLLLLEESWKE--FFILAMAQYLMPMNFAQLLFVYESENANREIMGMVTREV----- 310
            |.:|.:.||:.||:....|  |.:||..     ||...||.....        |.:|||.
Zfish   300 FADLDLNDQVTLLKYGVYEALFTLLASC-----MNKDGLLVAQGG--------GFITREFLKSLR 351

  Fly   311 HAFQEVLN-------QLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSA 368
            ..|.:::.       :...|.:|.::      ::||              .::|:.....|..|.
Zfish   352 KPFSDMMEPKFQFAMKFNALELDDSD------LALF--------------VAAIICCGDRPGLSN 396

  Fly   369 SAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLL--------------GVVQLMHK 419
            ..:...:.||    .:|     :|..::...||...:.|..||              .:||.::|
Zfish   397 VPQIERIQES----VIH-----SLRLHLTSNHPDNSLLFPKLLQKLADLRQLVTEHAELVQEINK 452

  Fly   420 VSSFTIEELFFRKTIGDITIVRLISDMY 447
            ....::..|          :..:..|||
Zfish   453 TEDASLHPL----------LQEIYRDMY 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	39/105 (37%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	46/281 (16%)
pparaa	NP_001154805.1	NR_DBD_Ppar	98..181	CDD:143523	37/86 (43%)
pparaa	NP_001154805.1	NR_LBD_PPAR	199..469	CDD:132730	57/380 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910