DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tll and pparab

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001096037.1	Gene:	pparab / 557714	ZFINID:	ZDB-GENE-990415-211	Length:	459	Species:	Danio rerio

Alignment Length:	478	Identity:	118/478 - (24%)
Similarity:	192/478 - (40%)	Gaps:	106/478 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QSSEGSPDMMDQKYNSVRLSPAAS-SRILYHVP--------------CKVCRDHSSGKHYGIYAC 51
            ||..||......:.::  |:||:| |..:|..|              |:||.|.:||.|||::||
Zfish    52 QSGLGSGSESSTELDA--LTPASSPSSGVYGCPVGQDEFTSTSLNLECRVCSDRASGYHYGVHAC 114

  Fly    52 DGCAGFFKRSIRRSRQY-VCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNS 115
            :||.|||:|:||...:| .|:.:    |.:.|.:||:|:.||.:||..|||:.:|::..|.|::.
Zfish   115 EGCKGFFRRTIRLKLEYDKCERR----CKIQKKNRNKCQYCRFQKCLSVGMSHNAIRFGRMPQSE 175

  Fly   116 TLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPS 180
            .||                  :.|||      |||...|......|.::.  :.|::..|....|
Zfish   176 KLR------------------LKAEI------LTGERDVEDDQKTLAKQI--YEAYVKNFNMNKS 214

  Fly   181 AAAVLDLSVPRVPHHPVHQ------GHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEH 239
            .|..:.......|...:|.      ....|    .|.|.......|...|.:......:.|:.|.
Zfish   215 KARTILTGKTSTPPFVIHDMETLQLAEQTF----VAKMMGSCGGLLNKDPEVRIFHCCQCTSVET 275

  Fly   240 LFKNVNWIKSVRAFTELPMPDQLLLLEESWKE--FFILAMAQYLMPMNFAQLLFVYESENANREI 302
            :.:...:.|||..|:.|.:.||:.||:....|  |.:||..     ||...||..|.|....||.
Zfish   276 VTELTEFAKSVPGFSNLDLNDQVTLLKYGVHEALFAMLASC-----MNKDGLLVAYGSGFITREF 335

  Fly   303 MGMVTREVHAFQEVLNQLC----HLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGS 363
            :..:.|......|...|..    .|.:|.::      ::||              .::|:.....
Zfish   336 LKSLRRPFSDMMEPKFQFAMKFNSLELDDSD------LALF--------------VAAIICCGDR 380

  Fly   364 PNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQ----PMRFQTLLGVVQLMHKVSSFT 424
            |         ||:....:..|.....:.||.:::..||..    |...|.|:.:.||:.:.:..
Zfish   381 P---------GLVNVPHIERMQESIVNVLHLHLKSNHPDHGFLFPKLLQKLVDLRQLVTEHAQL- 435

  Fly   425 IEELFFRKTIGDITIVRLISDMY 447
            |:|:   |...|.::..|:.::|
Zfish   436 IQEI---KKTEDTSLHPLLQEIY 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	40/107 (37%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	49/230 (21%)
pparab	NP_001096037.1	NR_DBD_Ppar	96..179	CDD:143523	38/104 (37%)
		C4 zinc finger; ZnF_C4	97..161		31/67 (46%)
		NR_LBD_PPAR	193..458	CDD:132730	62/307 (20%)
		ligand binding domain of hormone receptors (HOLI)	279..429		41/183 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910