DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tll and rxraa

DIOPT Version :9

Sequence 1:NP_524596.1 Gene:tll / 43656 FlyBaseID:FBgn0003720 Length:452 Species:Drosophila melanogaster
Sequence 2:XP_005161240.1 Gene:rxraa / 555578 ZFINID:ZDB-GENE-070314-2 Length:500 Species:Danio rerio


Alignment Length:460 Identity:124/460 - (26%)
Similarity:190/460 - (41%) Gaps:112/460 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MQSSEGSPDMMDQ-KYNSVRLSPAASS----RILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKR 60
            |.|...|.|:... ..|.|...||..|    .:..|: |.:|.|.|||||||:|:|:||.|||||
Zfish   131 MNSVSSSEDIKPPLGLNGVMKVPAQPSGTPLSLTKHI-CAICGDRSSGKHYGVYSCEGCKGFFKR 194

  Fly    61 SIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKD-----AVQHERGPRNSTLRRH 120
            ::|:...|.|:..|.  ||:||..||:|:.||.:||..:||.::     |||.||          
Zfish   195 TVRKDLTYTCRDNKD--CVIDKRQRNRCQYCRYQKCLAMGMKREVLLHTAVQEER---------- 247

  Fly   121 MAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVL 185
                           |...|...|....|......||:..:.:      |.:|.   .|.....:
Zfish   248 ---------------QRAKERSENEVESTSSANEDMPVEKILE------AELAV---EPKTETYI 288

  Fly   186 DLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSV 250
            :.:||                             :|...|.....:|.:.|.:.||..|.|.|.:
Zfish   289 ETNVP-----------------------------MPSNSPNDPVTNICQAADKQLFTLVEWAKRI 324

  Fly   251 RAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMN----FAQLLFVYESENANREIMGMVTREVH 311
            ..|:|||:.||::||...|.|..|.:.:...:.:.    .|..|.|:.: :|:...:|.:...| 
Zfish   325 PHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRN-SAHSAGVGAIFDRV- 387

  Fly   312 AFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLL 376
             ..|:::::..:.:|.||..|||||.||                             :.:|:||.
Zfish   388 -LTELVSKMRDMQMDKTELGCLRAIVLF-----------------------------NPDSKGLS 422

  Fly   377 ESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVR 441
            ..|:|.|:.....::|..|.:..:|.||.||..||..:..:..:....:|.|||.|.|||..|..
Zfish   423 NPGEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDT 487

  Fly   442 LISDM 446
            .:.:|
Zfish   488 FLMEM 492

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tllNP_524596.1 NR_DBD_TLX 25..117 CDD:143537 43/100 (43%)
NR_LBD 215..436 CDD:416257 58/224 (26%)
rxraaXP_005161240.1 Nuc_recep-AF1 63..159 CDD:288658 9/27 (33%)
NR_DBD_RXR 166..247 CDD:143514 40/83 (48%)
NR_LBD_RXR_like 267..478 CDD:132741 63/280 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X118
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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